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Titolo:
TNF LYMPHOTOXIN-ALPHA DOUBLE-MUTANT MICE RESIST SEPTIC ARTHRITIS BUT DISPLAY INCREASED MORTALITY IN RESPONSE TO STAPHYLOCOCCUS-AUREUS/
Autore:
HULTGREN O; EUGSTER HP; SEDGWICK JD; KORNER H; TARKOWSKI A;
Indirizzi:
UNIV GOTHENBURG,DEPT RHEUMATOL,GULDHEDSGATAN 10 S-41346 GOTHENBURG SWEDEN UNIV ZURICH HOSP,CLIN IMMUNOL SECT CH-8091 ZURICH SWITZERLAND UNIV SYDNEY,CENTENARY INST CANC MED & CELL BIOL SYDNEY NSW 2006 AUSTRALIA INST NEUROBIOL HYG & IMMUNOL ERLANGEN GERMANY
Titolo Testata:
The Journal of immunology (1950)
fascicolo: 11, volume: 161, anno: 1998,
pagine: 5937 - 5942
SICI:
0022-1767(1998)161:11<5937:TLDMRS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; FOLLICULAR DENDRITIC CELLS; HUMAN ENDOTHELIAL-CELLS; RHEUMATOID-ARTHRITIS; LYMPHOTOXIN-ALPHA; DEFICIENT MICE; T-CELL; B-CELL; LISTERIA-MONOCYTOGENES; INFECTIOUS ARTHRITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
O. Hultgren et al., "TNF LYMPHOTOXIN-ALPHA DOUBLE-MUTANT MICE RESIST SEPTIC ARTHRITIS BUT DISPLAY INCREASED MORTALITY IN RESPONSE TO STAPHYLOCOCCUS-AUREUS/", The Journal of immunology (1950), 161(11), 1998, pp. 5937-5942

Abstract

To evaluate the importance of the proinflammatory cytokines TNF and lymphotoxin-alpha (LT alpha) in an experimental model of Staphylococcusaureus sepsis and arthritis, we used TNF/LT alpha-double-deficient mice raised on the C57BL/6 background, Mice were i.v. inoculated with a toxic shock syndrome toxin-1 (TSST-1)-producing S. aureus strain, LS-1. Intravenous inoculation of a high dose of bacteria (1 x 10(7)/mouse)resulted in 67% mortality in TNF/LT alpha-deficient mice, whereas none of the controls died (p = 0.009), Those results correlated to a significantly decreased phagocytosis in vitro and inefficient bacterial clearance in vivo in mice lacking capacity to produce TNF/LT alpha. Thus, at day 6 after inoculation, S, aureus could not be found in the bloodstream of controls, but bacteremia developed in all TNF/LT alpha-deficient mice examined (p = 0.02). Interestingly, upon infection with a lower dose of staphylococci (3 x 10(6)/mouse) the mortality was overalllow, but the frequency of arthritis was clearly higher in the wild-type group as compared with the TNF/LT alpha-deficient mice (40% vs 13%). Histopathologic examination revealed a lower frequency of synovitis (38% vs 90%, p < 0.05) and erosivity (25% vs 60%, NS) in TNF/LT alpha-deficient mice as compared with wild-type counterparts, Our results show the importance of TNF/LT alpha in defense against systemic S, aureus infections and point out the detrimental role of these cytokines as mediators of inflammatory response in S, aureus arthritis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:56:35