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Titolo:
MODULATION OF SENSORY NERVE FUNCTION IN THE AIRWAYS
Autore:
SPINA D; SHAH S; HARRISON S;
Indirizzi:
UNIV LONDON KINGS COLL,SACKLER INST PULM PHARMACOL,DEPT RESP MED,BESSEMER RD LONDON SE5 9PJ ENGLAND
Titolo Testata:
Trends in pharmacological sciences
fascicolo: 11, volume: 19, anno: 1998,
pagine: 460 - 466
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG AIRWAYS; NONADRENERGIC NONCHOLINERGIC CONTRACTION; INDUCED BRONCHIAL HYPERRESPONSIVENESS; CAPSAICIN-SENSITIVE NEURONS; GABA-AGONIST BACLOFEN; SUBSTANCE-P; ASTHMATIC SUBJECTS; SODIUM CROMOGLYCATE; NEDOCROMIL SODIUM; INDUCED BRONCHOCONSTRICTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
121
Recensione:
Indirizzi per estratti:
Citazione:
D. Spina et al., "MODULATION OF SENSORY NERVE FUNCTION IN THE AIRWAYS", Trends in pharmacological sciences, 19(11), 1998, pp. 460-466

Abstract

Several clinical studies document a greater discrimination between asthmatic and healthy subjects in bronchial responsiveness to a range ofstimuli such as cold air, distilled water and sodium metabisulphite, than to conventional bronchoconstrictor agonists including histamine and methacholine. One of the mechanisms thought to account for the bronchoconstriction induced by these agents is via reflex activation of the cholinergic pathway. An increase in sensory nerve (afferent) activity in asthma might account for the increased responsiveness to these agents. If so, a number of strategies are available to inhibit the function of afferent nerves which could lead to a suppression of bronchial hyperresponsiveness, including (1) inhibition of afferent activity, (2) inhibition of neuropeptide release and (3) antagonism of tachykinin receptors. As there are numerous reviews dealing with the latter, in this review Domenico Spina, Saloni Shah and Selena Harrison focus on the first two strategies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 02:18:55