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Titolo:
OPTICAL-RESPONSES EVOKED BY SINGLE-PULSE STIMULATION TO THE DORSAL-ROOT IN THE RAT SPINAL DORSAL HORN IN SLICE
Autore:
IKEDA H; RYU PD; PARK JB; TANIFUJI M; ASAI T; MURASE K;
Indirizzi:
FUKUI UNIV,DEPT INFORMAT SCI,3-9-1 BUNKYO FUKUI 910 JAPAN FUKUI UNIV,DEPT INFORMAT SCI FUKUI 910 JAPAN SEOUL NATL UNIV,DEPT VET PHARMACOL & TOXICOL SUWON SOUTH KOREA RIKEN WAKO SAITAMA 35101 JAPAN
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 812, anno: 1998,
pagine: 81 - 90
SICI:
0006-8993(1998)812:1-2<81:OEBSST>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANTIA-GELATINOSA NEURONS; PRIMARY AFFERENT-FIBERS; LONG-TERM DEPRESSION; SYNAPTIC TRANSMISSION; EXCITATORY TRANSMISSION; GLUTAMATE EXCITATION; CUTANEOUS AFFERENTS; ELECTRICAL-ACTIVITY; FIELD POTENTIALS; AMINO-ACIDS;
Keywords:
ATP RECEPTOR; GLUTAMATE RECEPTOR; OPTICAL RECORDING; PAIN; PRIMARY EFFERENT FIBER; VOLTAGE-SENSITIVE DYE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
H. Ikeda et al., "OPTICAL-RESPONSES EVOKED BY SINGLE-PULSE STIMULATION TO THE DORSAL-ROOT IN THE RAT SPINAL DORSAL HORN IN SLICE", Brain research, 812(1-2), 1998, pp. 81-90

Abstract

Neuronal excitation evoked after dorsal-root (DR) stimulation in the spinal dorsal horn (DH) of rats was visualized with a high-resolution optical-imaging method, and the propagation mechanism was studied. Transverse slices of the spinal cord were obtained from 2-4 week-old ratsand stained with the voltage-sensitive dye RH-482. Single-pulse stimulation to the primary-afferent A fibers in the DR attached to the slice evoked a weak, brief (< 10 ms) excitatory optical response in the laminae I and III-V. When the stimulus intensity and duration were increased to activate both A and C fibers, an additional, much greater, andlonger-lasting (> 100 ms) excitatory response was generated in the laminae I-III, most intensely in the lamina II. A treatment with excitatory amino acid (EAA) antagonists, DL-2-amino-5-phosphonovaleric acid and 6-cyano-7-nitroquinoxaline-2,3-dione, significantly reduced the amplitude and duration of the response in the lamina II. The optical response in the antagonists-containing solution was quite similar to that recorded in a Ca2+-free solution that blocked afferent synaptic transmission. The late component(> 10 ms) was, however, slightly greater than that in the Ca2+-free solution. Treatment with the ATP-receptor antagonist, suramin, had a minimal effect on the response in the presence of EAA antagonists. These results suggested that the propagation of the DR-stimulus-elicited excitation was contributed largely by EAA receptors, but also by other receptors to a much lesser extent. (C) 1998 Elsevier Science B.V. All rights reserved.

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Documento generato il 09/04/20 alle ore 09:04:47