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Titolo:
NEW STRUCTURES ABLE TO PREVENT THE INHIBITION BY HYDROXYL RADICALS OFGLUTAMATE TRANSPORT IN CULTURED ASTROCYTES
Autore:
CAUQUILCAUBERE I; KAMENKA JM;
Indirizzi:
ECOLE NATL SUPER CHIM,CNRS UPR 1086,CRBM,8 RUE ECOLE NORMALE F-34296 MONTPELLIER 5 FRANCE ECOLE NATL SUPER CHIM,CNRS UPR 1086,CRBM F-34296 MONTPELLIER 5 FRANCE
Titolo Testata:
European journal of medicinal chemistry
fascicolo: 11, volume: 33, anno: 1998,
pagine: 867 - 877
SICI:
0223-5234(1998)33:11<867:NSATPT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL-CORD; NONCOMPETITIVE ANTAGONISTS; EXTRACELLULAR GLUTAMATE; OXYGEN; DAMAGE; CELLS; IRON; NEUROTOXICITY; DEOXYRIBOSE; EXTENSION;
Keywords:
FREE RADICALS; GLUTAMATE TRANSPORTERS; ASTROCYTES; NEUROPROTECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
I. Cauquilcaubere e J.M. Kamenka, "NEW STRUCTURES ABLE TO PREVENT THE INHIBITION BY HYDROXYL RADICALS OFGLUTAMATE TRANSPORT IN CULTURED ASTROCYTES", European journal of medicinal chemistry, 33(11), 1998, pp. 867-877

Abstract

4,5,6,7-Tetrahydro-benzothiophen-7-ylamines, 4,5,6,7-tetrahydro-benzothiophen-4-ylamines and 5,6-dihydro-4H-thieno[2,3-b] thiopyran-4-ylamines were designed, synthesized, and tested as OH. radical scavengers. Most of them displayed chemical scavenging properties better than or in the same range as salicylic acid. Moreover, some compounds were ableto protect in vitro the astroglial glutamate transporters against inhibitory action of radicals promoted by xanthine/xanthine oxidase. Thus, such compounds might be useful for lowering the large amounts of excitotoxic glutamate liberated during acute CNS diseases: they might protect the glutamate reuptake in astrocytes from the inhibitory action due to radicals co-liberated with glutamate. (C) Elsevier, Paris.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:32:03