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Titolo:
ELEVATED LEVELS OF BILE-ACIDS IN COLOSTRUM OF PATIENTS WITH CHOLESTASIS OF PREGNANCY ARE DECREASED FOLLOWING URSODEOXYCHOLIC ACID THERAPY
Autore:
BRITES D; RODRIGUES CMP;
Indirizzi:
UNIV NOVA LISBOA,FAC FARM,CTR PATOGENESE MOL,AV FORCAS ARMADAS P-1600LISBON PORTUGAL INST SUPER CIENCIAS SAUDE SUL MONTE DE CAPARICA PORTUGAL
Titolo Testata:
Journal of hepatology
fascicolo: 5, volume: 29, anno: 1998,
pagine: 743 - 751
SICI:
0168-8278(1998)29:5<743:ELOBIC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRA-HEPATIC CHOLESTASIS; CHROMATOGRAPHY MASS SPECTROMETRY; INTRAHEPATIC CHOLESTASIS; BREAST-MILK; PROGESTERONE METABOLITES; PHYSIOLOGIC CHOLESTASIS; LIQUID-CHROMATOGRAPHY; OBSTETRIC CHOLESTASIS; AMNIOTIC-FLUID; NORMAL INFANTS;
Keywords:
BILE ACIDS; CHOLESTASIS OF PREGNANCY; COLOSTRUM; SERUM; URSODEOXYCHOLIC ACID THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
D. Brites e C.M.P. Rodrigues, "ELEVATED LEVELS OF BILE-ACIDS IN COLOSTRUM OF PATIENTS WITH CHOLESTASIS OF PREGNANCY ARE DECREASED FOLLOWING URSODEOXYCHOLIC ACID THERAPY", Journal of hepatology, 29(5), 1998, pp. 743-751

Abstract

Background/Aims: Intrahepatic cholestasis of pregnancy is characterised by increased levels of serum bile acids. Ursodeoxycholic acid therapy corrects the serum bile acid profile. The aims of this study mere: (i) to investigate bile acid excretion into colostrum of women with intrahepatic cholestasis of pregnancy; (ii) to compare concentrations ofbile acids in serum and colostrum of non-treated and ursodeoxycholic acid-treated patients; and (iii) to clarify whether ursodeoxycholic acid is eliminated into colostrum following treatment. Methods: Bile acids were assessed by gas chromatography and high-performance liquid chromatography in serum collected at delivery, and in colostrum obtained at 2+/-1 days after labour, from patients with intrahepatic cholestasis of pregnancy, non-treated (n=9) and treated (n=7) with ursodeoxycholic acid (14 mg/kg bw per day, for 14+/-7 days) until parturition. Results: The concentration of total bile acids in colostrum from patients with intrahepatic cholestasis of pregnancy was higher than in normals (23.3+/-14.8 mu mol/l vs. 0.7+/-0.2 mu mol/l, p<0.01) and cholic acid was a major species (19.0+/-13.1 mu mol/l), reflecting the elevated concentrations in maternal serum (48.9+/-21.0 mu mol/l, total bile acids; 33.9+/-16.7 mu mol/l, cholic acid. Following ursodeoxycholic acid administration, total bile acids and cholic acid levels in colostrum diminished to 5.7+/-2.5 mu mol/l and 3.6+/-1.5 mu mol/l, respectively; the proportion of cholic acid decreased (60.6+/-8.0% vs. 76.8+/-5.0%, p<0.05). The ursodeoxycholic acid concentration in colostrum was maintained following treatment; its increased percentage (9.4+/-3.2% vs. 1.0+/-0.2%, p<0.01) was still lower than in maternal serum (20.8+/-3.6%, p<0.05). Only a small proportion (<1%) of lithocholic acid was found incolostrum following therapy. Conclusions: Bile acid concentrations are elevated and cholic acid is the major species accumulating in colostrum, reflecting serum bile acid profiles in intrahepatic cholestasis of pregnancy. Ursodeoxycholic acid therapy decreases endogenous bile acid levels in colostrum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:04:51