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Titolo:
TRANSCRANIAL CYTOKINE GRADIENTS IN PATIENTS REQUIRING INTENSIVE-CARE AFTER ACUTE BRAIN INJURY
Autore:
MCKEATING EG; ANDREWS PJD; SIGNORINI DF; MASCIA L;
Indirizzi:
UNIV EDINBURGH,WESTERN GEN HOSP,DEPT CLIN NEUROSCI EDINBURGH EH4 2XU MIDLOTHIAN SCOTLAND UNIV EDINBURGH,WESTERN GEN HOSP,DEPT ANAESTHET EDINBURGH EH4 2XU MIDLOTHIAN SCOTLAND UNIV BARI,DEPT INTENS CARE BARI ITALY
Titolo Testata:
British Journal of Anaesthesia
fascicolo: 5, volume: 78, anno: 1997,
pagine: 520 - 523
SICI:
0007-0912(1997)78:5<520:TCGIPR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAD-INJURY; RAT-BRAIN; IL-6; INTERLEUKIN-6; ELEVATION; SEPSIS; PLASMA;
Keywords:
BRAIN, INJURY; POLYPEPTIDES, CYTOKINES; INTENSIVE CARE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
E.G. Mckeating et al., "TRANSCRANIAL CYTOKINE GRADIENTS IN PATIENTS REQUIRING INTENSIVE-CARE AFTER ACUTE BRAIN INJURY", British Journal of Anaesthesia, 78(5), 1997, pp. 520-523

Abstract

After acute brain injury there may be increased intracranial production of cytokines, with activation of inflammatory cascades. We have sought to determine if a transcranial cytokine gradient was demonstrable in paired sera of 32 patients requiring intensive care after acute brain injury. The difference between concentrations of IL-1 beta, IL-6, IL-8 and TNF alpha in jugular venous and arterial serum was measured onadmission, and at 24, 48 and 96 h after the primary injury. There were no differences in IL-1 beta, IL-8 or TNF alpha, but median gradientsof 6.7 and 11.5 pg ml(-1) for IL-6 were demonstrated in the traumaticbrain injury (n=22) and subarachnoid haemorrhage (n=10) groups, respectively (normal values in serum <4.7 pg ml(-1); P<0.001 both groups). This suggests that there is significant production of IL-6 by intracranial cells after acute brain injury. Therapy directed towards combatting the negative effects of IL-6 may potentially benefit patients who have sustained an acute brain injury.

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Documento generato il 18/09/20 alle ore 16:06:59