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Titolo:
CHANGES IN-FIELD POTENTIALS AND MEMBRANE CURRENTS IN RAT SENSORIMOTORCORTEX FOLLOWING REPEATED TETANIZATION OF THE CORPUS-CALLOSUM IN-VIVO
Autore:
CHAPMAN CA; TREPEL C; IVANCO TL; FROC DJ; WILSON K; RACINE RJ;
Indirizzi:
MCMASTER UNIV,DEPT PSYCHOL HAMILTON ON L8S 4K1 CANADA MCMASTER UNIV,DEPT PSYCHOL HAMILTON ON L8S 4K1 CANADA
Titolo Testata:
Cerebral cortex (New York, N.Y. 1991)
fascicolo: 8, volume: 8, anno: 1998,
pagine: 730 - 742
SICI:
1047-3211(1998)8:8<730:CIPAMC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; POST-ACTIVATION POTENTIATION; SOURCE-DENSITY ANALYSIS; PRIMARY VISUAL-CORTEX; MOTOR CORTEX; EVOKED-POTENTIALS; PIRIFORM CORTEX; HORIZONTAL CONNECTIONS; LASTING POTENTIATION; SYNAPTIC PLASTICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Chapman et al., "CHANGES IN-FIELD POTENTIALS AND MEMBRANE CURRENTS IN RAT SENSORIMOTORCORTEX FOLLOWING REPEATED TETANIZATION OF THE CORPUS-CALLOSUM IN-VIVO", Cerebral cortex (New York, N.Y. 1991), 8(8), 1998, pp. 730-742

Abstract

Repeated, daily tetanization of the corpus callosum induces lasting changes in sensorimotor cortex field potential responses, but the synaptic populations that mediate these responses and support long-term potentiation (LTP) have not been characterized. Current source density analyses of field responses were compared between control animals and those in which LTP was induced by 10 daily series of tetanizations. Tetanization and paired-pulse stimulation (100 ms interval) enhanced the duration of initial (similar to 3 ms onset) deep-negative population spike activity generated by a current sink in layer V that peaked repeatedly at a frequency of similar to 400 Hz. The early (similar to 10 ms to peak) surface-negative component of field responses was generated by a current sink in upper layer V and a source in layer VI. This monosynaptic component followed high stimulation frequencies, recovered quickly from the effects of anaesthesia, and was enhanced by both tetanization and paired-pulse stimulation. The late (similar to 20 ms to peak) surface-negative component was generated by a sink in upper layer V and a source deep in layer V, and was greatly enhanced by tetanizationand paired-pulse stimulation. The late component did not follow high-frequency stimulation and recovered slowly from anaesthesia, suggesting that it is driven polysynaptically. potentiation of monosynaptic thalamic and cortico-cortical afferents probably mediates enhancements ofthe early component and population spikes, while potentiation of polysynaptic afferents to layer V may contribute to growth in the late component.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 23:52:47