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Titolo:
IMPAIRED PERIPHERAL VASOCONSTRICTION IN RESPONSE TO ALPHA-ADRENERGIC STIMULATION IN PATIENTS WITH IDIOPATHIC HYPERTROPHIC CARDIOMYOPATHY
Autore:
KAWANO S; IIDA K; NISHI I; IWASAKI Y; MASUMI T; SUGISHITA Y; YAMAGUCHI I;
Indirizzi:
UNIV TSUKUBA,INST CLIN MED,DEPT INTERNAL MED,DIV CARDIOVASC,TENNODAI 1-1-1 TSUKUBA IBARAKI 3058575 JAPAN UNIV TSUKUBA,INST CLIN MED,DEPT INTERNAL MED,DIV CARDIOVASC TSUKUBA IBARAKI 3058575 JAPAN TSUKUBA MEM HOSP IBARAKI OSAKA JAPAN
Titolo Testata:
Japanese Circulation Journal
fascicolo: 12, volume: 62, anno: 1998,
pagine: 903 - 908
SICI:
0047-1828(1998)62:12<903:IPVIRT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUDDEN CARDIAC DEATH; BETA-MYOSIN; EXERCISE; EXPRESSION; MUTATIONS; SYNCOPE; AGE;
Keywords:
ALPHA-ADRENERGIC STIMULATION; HYPERTROPHIC CARDIOMYOPATHY; PERIPHERAL VASCULATURE; VASOCONSTRICTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
S. Kawano et al., "IMPAIRED PERIPHERAL VASOCONSTRICTION IN RESPONSE TO ALPHA-ADRENERGIC STIMULATION IN PATIENTS WITH IDIOPATHIC HYPERTROPHIC CARDIOMYOPATHY", Japanese Circulation Journal, 62(12), 1998, pp. 903-908

Abstract

Exercise hypotension has been documented in patients with hypertrophic cardiomyopathy (HCM). Some investigators reported that this is due to an inadequate increase of systemic vascular resistance during or after exercise. The aim of this study was to investigate the pathogenesisof limb vascular response abnormalities in patients with idiopathic HCM. Thirteen patients with HCM and 9 healthy controls were administered an endothelium-dependent dilator (acetylcholine), a direct smooth muscle dilator (nitroglycerin), an alpha-adrenergic stimulator (phenylephrine), and a beta-adrenergic stimulator (isoproterenol) by intra-arterial infusion. Peripheral vascular resistance was assessed by forearm plethysmography at rest and during each infusion to obtain the percentage change in vascular resistance. Isoproterenol, acetylcholine and nitroglycerin produced dose-related vasodilatation with no significant differences between HCM patients and healthy controls. The percentage increase in vascular resistance was significantly less in HCM patients than in healthy controls after phenylephrine infusions of 0.5 mu g/min(155+/-38% vs 195+/-47%, mean +/- SD, p<0.05) and 1.0 mu g/min (174+/-49% vs 238+/-65%, p<0.05). Vasoconstriction mediated by alpha-adrenergic receptors appeared to be impaired in the peripheral vasculature ofpatients with HCM.

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Documento generato il 02/07/20 alle ore 22:08:04