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Titolo:
FELINE IMMUNODEFICIENCY VIRUS-ASSOCIATED MYOPATHY IN THE ADULT CAT
Autore:
PODELL M; CHEN E; SHELTON GD;
Indirizzi:
OHIO STATE UNIV,COLL VET MED,DEPT VET CLIN SCI COLUMBUS OH 43210 OHIO STATE UNIV,CTR COMPREHENS CANC COLUMBUS OH 43210 UNIV CALIF SAN DIEGO,DEPT PATHOL,COMPARAT NEUROMUSCULAR LAB LA JOLLA CA 92093
Titolo Testata:
Muscle & nerve
fascicolo: 12, volume: 21, anno: 1998,
pagine: 1680 - 1685
SICI:
0148-639X(1998)21:12<1680:FIVMIT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE ENCEPHALOPATHY; NEUROMUSCULAR DISEASES; POLYMYOSITIS; AIDS; INFECTION; MONKEYS; HTLV-1;
Keywords:
MYOPATHY; HUMAN IMMUNODEFICIENCY VIRUS; FELINE IMMUNODEFICIENCY VIRUS; CATS; POLYMYOSITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M. Podell et al., "FELINE IMMUNODEFICIENCY VIRUS-ASSOCIATED MYOPATHY IN THE ADULT CAT", Muscle & nerve, 21(12), 1998, pp. 1680-1685

Abstract

Human immunodeficiency virus (HIV-1) associated myopathy can be a debilitating disease in humans, leading to weakness, myalgia, and muscle wasting. Subclinical neuromuscular involvement is also common. A rangeof histologic lesions have been described in both forms that include both inflammatory and degenerative changes. The purpose of this study was to determine whether a myopathy was present in adult cats experimentally infected with feline immunodeficiency virus (FIV). Six specificpathogen-free, laboratory-housed cats were challenged intravenously with 1000 TCID50 of the Maryland isolate of FIV (FIV-MD) at 8 months ofage. The highest serum creatine kinase values were seen at 18 months postinfection (mean 9838, SD 4805 U/L) compared to preinfection (mean 950, SD 374 U/L). Needle EMG studies revealed abnormal spontaneous activity in 2 cats. All FIV-MD infected cats exhibited at least one abnormality in muscle pathology. Of the 24 muscle samples, 15 (63%) had histopathologic lesions. The predominant histologic abnormalities consisted of perivascular and pericapillary lymphocytic infiltration, and myofiber necrosis, phagocytosis, and regeneration. Lymphocytic infiltration was graded 2+ or higher in 12 of 24 muscle samples (0 = negligible;4+ = extensive). Immunohistochemical phenotypic lymphocyte labeling in all cats demonstrated only CD8+ lymphocyte staining. This report demonstrates the presence of a FIV associated inflammatory myopathy in the adult cat. Several similarities are apparent in comparison to HIV-1 associated polymyositis reported in humans. Future studies in the cat may thus prove useful in elucidating the pathogenesis of retrovirus related myopathy in humans. (C) 1998 John Wiley & Sons, Inc.

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Documento generato il 02/12/20 alle ore 16:49:09