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Titolo:
EFFECT OF COADMINISTRATION OF GLUTAMATE-RECEPTOR ANTAGONISTS AND DOPAMINERGIC AGONISTS ON LOCOMOTION IN MONOAMINE-DEPLETED RATS
Autore:
GOSSEL M; SCHMIDT WJ; LOSCHER W; ZAJACZKOWSKI W; DANYSZ W;
Indirizzi:
MERZ & CO,DEPT PHARMACOL,POB 111353 D-60048 FRANKFURT GERMANY MERZ & CO,DEPT PHARMACOL D-60048 FRANKFURT GERMANY UNIV TUBINGEN,INST ZOOL,DEPT NEUROPHARMACOL TUBINGEN GERMANY HANNOVER SCH VET MED,INST PHARMACOL TOXICOL & PHARM HANNOVER GERMANY
Titolo Testata:
Journal of neural transmission. Parkinson's disease and dementia section
fascicolo: 1, volume: 10, anno: 1995,
pagine: 27 - 39
SICI:
0936-3076(1995)10:1<27:EOCOGA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MPTP-TREATED MONKEYS; PARKINSONS-DISEASE; BASAL GANGLIA; SUBTHALAMIC NUCLEUS; D2 AGONIST; L-DOPA; BROMOCRIPTINE; MK-801; RESPONSES; NBQX;
Keywords:
LOCOMOTION; MONOAMINE-DEPLETION; RESERPINE ALPHA-METHYL-P-TYROSINE; (+)-MK-801; NBQX; SKF 38393; SKF 82958; DIHYDREXIDINE; BROMOCRIPTINE; L-DOPA; RATS; D1 RECEPTOR AGONISTS; D2 RECEPTOR AGONIST; NMDA RECEPTOR ANTAGONIST; AMPA RECEPTOR ANTAGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
M. Gossel et al., "EFFECT OF COADMINISTRATION OF GLUTAMATE-RECEPTOR ANTAGONISTS AND DOPAMINERGIC AGONISTS ON LOCOMOTION IN MONOAMINE-DEPLETED RATS", Journal of neural transmission. Parkinson's disease and dementia section, 10(1), 1995, pp. 27-39

Abstract

Combinations of dopaminergic agonists with glutamate receptor antagonists have been suggested to be a possible alternative treatment of Parkinson's disease. To gain further insights into this possibility, the antagonist of the competitive AMPA-type glutamate receptor NBQX and the ion-channel blocker of the NMDA glutamate receptor (+)-MK-801 in combination with the dopamine D1 receptor agonists: SKF 38393, SKF 82958,and dihydrexidine; the dopamine D2 receptor agonist bromocriptine andthe dopamine-precursor L-DOPA were tested in rats pretreated with reserpine and a-methyl-p-tyrosine. MK-801 on its own induced locomotor behaviour and potentiated the antiakinetic effects of dihydrexidine and L-DOPA but not of the other dopamine agonists tested. NBQX neither on its own nor coadministered with the dopamine agonists tested had an antiakinetic effect. These results indicate that agents, blocking the ion-channel of the NMDA receptor, might be useful adjuvants to some but not all dopaminomimetics in therapy of Parkinson's disease. The same does not seem to be true for the AMPA-antagonist NBQX.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:36:29