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Titolo:
CHRONIC TREATMENT WITH THE UNCOMPETITIVE NMDA RECEPTOR ANTAGONIST MEMANTINE INFLUENCES THE POLYAMINE AND GLYCINE BINDING-SITES OF THE NMDA RECEPTOR COMPLEX IN AGED RATS
Autore:
BRESINK I; DANYSZ W; PARSONS CG; TIEDTKE P; MUTSCHLER E;
Indirizzi:
MERZ & CO GMBH & CO,DEPT PHARMACOL,ECKENHEIMER LANDSTR 100-104 D-60318 FRANKFURT GERMANY UNIV FRANKFURT,INST PHARMACOL,BIOZENTRUM NIEDERURSEL W-6000 FRANKFURTGERMANY
Titolo Testata:
Journal of neural transmission. Parkinson's disease and dementia section
fascicolo: 1, volume: 10, anno: 1995,
pagine: 11 - 26
SICI:
0936-3076(1995)10:1<11:CTWTUN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; H-3 MK-801 BINDING; HUMAN FRONTAL-CORTEX; CEREBRAL-CORTEX; MEDIATED NEUROTOXICITY; )H-3>MK-801 BINDING; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; CORTICAL MEMBRANES; GLUTAMATE;
Keywords:
MEMANTINE; N-METHYL-D-ASPARTATE (NMDA); AGING; [H-3] MK-801; [H-3] ]GLYCINE; SPERMIDINE; RADIAL MAZE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
I. Bresink et al., "CHRONIC TREATMENT WITH THE UNCOMPETITIVE NMDA RECEPTOR ANTAGONIST MEMANTINE INFLUENCES THE POLYAMINE AND GLYCINE BINDING-SITES OF THE NMDA RECEPTOR COMPLEX IN AGED RATS", Journal of neural transmission. Parkinson's disease and dementia section, 10(1), 1995, pp. 11-26

Abstract

Receptor binding studies on rat cortical membranes were used to characterize the NMDA receptor in aged rats (22 months) treated for 20 months with a memantine containing diet delivering 30 mg/kg/day in comparison to aged and young/adult rats treated with control-diet. Spatial memory impairing effects of (+)-MK-801 (0.16 mg/kg) in the radial maze was not altered within the course of memantine-treatment (up to 16 months). However, chronic memantine-treatment significantly increased the number of [H-3]MK-801 binding sites and the affinity of [H-3]glycine. A non-significant trend to such changes was also seen in aged-control rats. Glycine-dependent [H-3]MK-801 binding (functional binding under non-equilibrium conditions at a fixed L-glutamate concentration) revealed that a decreased ability of glycine to stimulate channel opening in aged rats was partially attenuated by the longterm memantine treatment. Furthermore, an increased ability of spermidine to enhance [H-3]MK-801 binding in aged-control rats was even more pronounced in the agedmemantine-treated group. Together these findings may indicate that changes in functional receptor-channel properties during the process of aging occur prior to a detectable loss of binding sites and that memantine enhances an endogenous compensatory mechanism triggered by glutamatergic hypofunction which is suggested to take place in aging.

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Documento generato il 01/04/20 alle ore 01:24:13