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Titolo:
SPORADIC MEDULLARY MICROCARCINOMA OF THE THYROID - A RETROSPECTIVE ANALYSIS OF 80 CASES
Autore:
BERESSI N; CAMPOS JM; BERESSI JP; FRANC B; NICCOLISIRE P; CONTEDEVOLX B; MURAT A; CARON P; BALDET L; KRAIMPS JL; COHEN R; BIGORGNE JC; CHABRE O; LECOMTE P; MODIGLIANI E;
Indirizzi:
UNIV PARIS 13,HOP AVICENNE,DEPT ENDOCRINOL,125 ROUTE STALINGRAD F-93009 BOBIGNY FRANCE UNIV PARIS 13,HOP AVICENNE,DEPT ENDOCRINOL F-93009 BOBIGNY FRANCE CHU TIMONE,GETC STUDY GRP MARSEILLE FRANCE
Titolo Testata:
Thyroid
fascicolo: 11, volume: 8, anno: 1998,
pagine: 1039 - 1044
SICI:
1050-7256(1998)8:11<1039:SMMOTT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-CELL HYPERPLASIA; RET PROTOONCOGENE MUTATIONS; ROUTINE MEASUREMENT; SERUM CALCITONIN; STIMULATION TEST; MEN 2A; CARCINOMA; AUTOPSY; DIAGNOSIS; FAMILIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
N. Beressi et al., "SPORADIC MEDULLARY MICROCARCINOMA OF THE THYROID - A RETROSPECTIVE ANALYSIS OF 80 CASES", Thyroid, 8(11), 1998, pp. 1039-1044

Abstract

Clinical characteristics and prognosis of 80 patients (53 women and 27 men) with sporadic medullary thyroid carcinomas (MTC), less than 1 cm in size (micro-MTC), operated on between 1971 and 1996 are reported (73 total and 7 partial thyroidectomies). These patients, obtained from a national database of 899 patients with MTC, were compared with 357cases of sporadic MTC greater than 1 cm and 149 subjects with familial MTC less than 1 cm (familial micro-MTC). Median age at surgery was 52.5 years, a distribution similar to larger sporadic MTC. Micro-MTC was identified due to elevated calcitonin (47.5%), clinically identifiedlymph node (10.0%.), distant metastases (6.3%) or pathologic finding at surgery (36.2%). Diarrhea and/or flushing were observed in 6 patients including 4 with clinically identified lymph node. Among patients who had lymphnode dissection at surgery (68.8%), lymph node involvementwith tumor was observed in 30.9%, and was significantly more frequentin multifocal (7/11) than in unifocal micro-MTC (p < 0.03). All sporadic micro-MTC were unilateral. Survival rate was 93.9% +/- 4.4% (SE) at 10 years, greater than that observed in sporadic macro-MTC (p = 0.04). Normal postoperative basal calcitonin (CT) was obtained in 71.1% ofmicro-MTC patients versus 33.6% in sporadic macro-MTC (p < 0.01). Sporadic micro-MTC is much more frequent than expected, 15% of MTC in ourseries. Although specific survival rate and percentage of biological cure in micro-MTC are significantly better than for larger tumors, thefrequency of lymph node involvement, however, justifies an aggressivesurgical approach including total thyroidectomy and bilateral centrallymph node dissection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 16:08:13