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Titolo:
EVOKED QUANTAL CURRENTS AT NEUROMUSCULAR-JUNCTIONS OF WILD-TYPE DROSOPHILA LARVAE
Autore:
HECKMANN M; DUDEL J;
Indirizzi:
TECH UNIV MUNICH,INST PHYSIOL,BIEDERSTEINER STR 29 D-80802 MUNICH GERMANY
Titolo Testata:
Neuroscience letters
fascicolo: 2, volume: 256, anno: 1998,
pagine: 77 - 80
SICI:
0304-3940(1998)256:2<77:EQCANO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE-RECEPTOR CHANNELS; CRAYFISH MUSCLE; SYNAPTIC TRANSMISSION; NEUROTRANSMITTER; DESENSITIZATION; RELEASE; DISCHARGE; PATCHES; RESENSITIZATION; ACTIVATION;
Keywords:
CHANNEL; GLUTAMATE; KINETICS; EXCITATORY POSTSYNAPTIC CURRENTS; NEUROMUSCULAR JUNCTION; SYNAPSE; SYNAPTIC FUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
M. Heckmann e J. Dudel, "EVOKED QUANTAL CURRENTS AT NEUROMUSCULAR-JUNCTIONS OF WILD-TYPE DROSOPHILA LARVAE", Neuroscience letters, 256(2), 1998, pp. 77-80

Abstract

Evoked excitatory postsynaptic currents (EPSC) were recorded with an extracellular macropatch electrode from glutamatergic neuromuscular junctions of Drosophila larvae. At 20 degrees C quantal current amplitude was about -400 pA and the 10-90% rise time was slightly below 0.2 msfor the fastest rising events and on average 0.3 +/- 0.1 ms in our best recordings. The quantal currents often had 'shoulders' but decayed approximately monoexponentially from half amplitude. The time constantof the exponential fit varied with mean values ranging from 2.5 ms to7.7 ms in 13 experiments and an average value of 4.4 +/- 1.6 ms. Comparison of these results with data obtained earlier with outside-out patches of larval muscle membrane (Heckmann, M. and Dudel, J., Biophys. J., 72 (1997) 2160-2169) leads us to conclude that glutamate has to reach a saturating peak concentration of at least 10 mM in the synaptic cleft to allow the observed short quantal current rise times. To account for the time course of the quantal current decay one has to assume that the glutamate concentration in the synaptic cleft remains in the millimolar range for more than a millisecond and that the time course of the decay of the quantal currents is in part due to desensitizationof the postsynaptic receptor channels. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:51:48