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Titolo:
SEROTONIN RECEPTOR 1A KNOCKOUT - AN ANIMAL-MODEL OF ANXIETY-RELATED DISORDER
Autore:
RAMBOZ S; OOSTING R; AMARA DA; KUNG HF; BLIER P; MENDELSOHN M; MANN JJ; BRUNNER D; HEN R;
Indirizzi:
COLUMBIA UNIV,CTR NEUROBIOL & BEHAV,722 W 168TH ST,PI ANNEX 731 NEW YORK NY 10032 COLUMBIA UNIV,CTR NEUROBIOL & BEHAV NEW YORK NY 10032 UNIV PENN,DEPT RADIOL PHILADELPHIA PA 19104 SOLVAY PHARMACEUT WEESP NETHERLANDS MCGILL UNIV,NEUROBIOL PSYCHIAT UNIT MONTREAL PQ H3T 1E2 CANADA NEW YORK STATE PSYCHIAT INST & HOSP,DEPT NEUROSCI NEW YORK NY 10032 COLUMBIA UNIV,DEPT DEV PSYCHOBIOL NEW YORK NY 10032 CUNY HUNTER COLL,DEPT PSYCHOL NEW YORK NY 10021
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 24, volume: 95, anno: 1998,
pagine: 14476 - 14481
SICI:
0027-8424(1998)95:24<14476:SR1K-A>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; SUICIDE VICTIMS; BINDING-SITES; DEPRESSION; 5-HT; MICE; MODULATION; AGONISTS; CORTEX; STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
S. Ramboz et al., "SEROTONIN RECEPTOR 1A KNOCKOUT - AN ANIMAL-MODEL OF ANXIETY-RELATED DISORDER", Proceedings of the National Academy of Sciences of the United Statesof America, 95(24), 1998, pp. 14476-14481

Abstract

To investigate the contribution of individual serotonin (5-hydroxytryptamine; 5-HT) receptors to mood control, we have used homologous recombination to generate mice lacking specific serotonergic receptor subtypes. In the present report, we demonstrate that mice without 5-HT1A receptors display decreased exploratory activity and increased fear of aversive environments (open or elevated spaces). 5-HT1A knockout mice also exhibited a decreased immobility in the forced swim test, an effect commonly associated with antidepressant treatment. Although 5-HT1A receptors are involved in controlling the activity of serotonergic neurons, 5-HT1A knockout mice had normal levels of 5-HT and 5-hydroxyindoleacetic acid, possibly because of an up-regulation of 5-HT1B autoreceptors. Heterozygote 5-HT1A mutants expressed approximately one-half ofwild-type receptor density and displayed intermediate phenotypes in most behavioral tests. These results demonstrate that 5-HT1A receptors are involved in the modulation of exploratory and fear-related behaviors and suggest that reductions in 5-HT1A receptor density due to genetic defects or environmental stressors might result in heightened anxiety.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:50:00