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Titolo:
A PET STUDY ON THE ACUTE EFFECT OF ETHANOL ON STRIATAL D2 DOPAMINE-RECEPTORS WITH [C-11] RACLOPRIDE IN HEALTHY-MALES
Autore:
SALONEN I; HIETALA J; LAIHINEN A; LEHIKOINEN P; LEINO L; NAGREN K; RUOTSALAINEN U; OIKONEN V; TUOKKOLA T; NANTO V;
Indirizzi:
KYMENLAAKSO CENT HOSP,CLIN CHEM LAB FIN-48210 KOTKA FINLAND UNIV TURKU,CENT HOSP,CENT LAB FIN-20520 TURKU FINLAND UNIV TURKU,DEPT PSYCHIAT TURKU FINLAND UNIV TURKU,CYCLOTRON PET CTR FIN-20520 TURKU FINLAND UNIV TURKU,DEPT CLIN CHEM TURKU FINLAND
Titolo Testata:
Human psychopharmacology
fascicolo: 2, volume: 12, anno: 1997,
pagine: 145 - 152
SICI:
0885-6222(1997)12:2<145:APSOTA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; PARKINSONS-DISEASE; C-11 RACLOPRIDE; HUMAN-BRAIN; ALCOHOL; BINDING; DENSITIES; INVITRO; GENE;
Keywords:
ETHANOL; DOPAMINE; PET; STRIATUM; RACLOPRIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
I. Salonen et al., "A PET STUDY ON THE ACUTE EFFECT OF ETHANOL ON STRIATAL D2 DOPAMINE-RECEPTORS WITH [C-11] RACLOPRIDE IN HEALTHY-MALES", Human psychopharmacology, 12(2), 1997, pp. 145-152

Abstract

The effect of acute oral ethanol intake (1.0 g/kg) on cerebral D2-receptors ([C-11]raclopride binding) was studied in seven healthy volunteers, using water and alcohol in two separate 59-min PET sessions. In the alcohol experiments, the blood ethanol concentration at the beginning of the imaging was 26.4+/-3.8 mmol/l and remained stable during thePET session. Ethanol was not found to influence binding of [C-11]raclopride to the dopamine D2 receptors in the human striatum, as indicated by the unchanged ratio B-max/K-d of the whole (left and right) striatum. The T-max values of the control and ethanol experiments did not differ in the whole striatum, but the right to left difference of striatal T-max was turned from negative to positive by ethanol (P=0.02). However, the difference between hemispheres in B-max/K-d was not significantly altered by ethanol intake. There was considerable interindividual variation in the response of all the above parameters to acute ethanol exposure. According to the present results, the acute effects of peroral ethanol exposure on striatal D2 receptor binding potential are of relatively small magnitude in man. However, the changes in T-max suggest that ethanol may influence the right-left difference of [C-11]raclopride binding. (C) 1997 by John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:24:08