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Titolo:
AUTOANTIBODIES TO PHOSPHOLIPIDS AND TO THE COAGULATION PROTEINS IN AIDS
Autore:
ABUAF N; LAPERCHE S; RAJOELY B; CARSIQUE R; DESCHAMPS A; ROUQUETTE AM; BARTHET C; KHALED Z; MARBOT C; SAAB N; ROZEN J; GIRARD PM; ROZENBAUM W;
Indirizzi:
HOP ROTHSCHILD,SERV IMMUNOL & HEMATOL BIOL,33 BLVD PICPUS F-75571 PARIS 12 FRANCE HOP TENON,SERV HEMATOL & IMMUNOL BIOL F-75970 PARIS FRANCE HOP ROTHSCHILD,SERV MALAD INFECT & TROP F-75571 PARIS 12 FRANCE
Titolo Testata:
Thrombosis and haemostasis
fascicolo: 5, volume: 77, anno: 1997,
pagine: 856 - 861
SICI:
0340-6245(1997)77:5<856:ATPATT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; ANTI-CARDIOLIPIN ANTIBODIES; LINKED IMMUNOSORBENT-ASSAY; ANTICARDIOLIPIN ANTIBODIES; ANTIPHOSPHOLIPID ANTIBODIES; AUTOIMMUNE DISORDERS; HIV-INFECTION; ANTICOAGULANT; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
N. Abuaf et al., "AUTOANTIBODIES TO PHOSPHOLIPIDS AND TO THE COAGULATION PROTEINS IN AIDS", Thrombosis and haemostasis, 77(5), 1997, pp. 856-861

Abstract

In HIV-1 infection, an increased prevalence of anticardiolipin autoantibodies (aCL) and lupus anticoagulant (LA) has been described. In order to see if these antibodies are isolated or, like in autoimmune diseases, associated with hematological disorders and with antibodies to other phospholipids and to proteins of coagulation, we investigated 3 groups of patients: 1. 342 HIV-1 infected patients, 2. 145 control patients including 61 systemic lupus erythematosus (SLE) patients, 58 patients with a connective tissue disease, 15 patients with stroke, 11 patients with syphilis and 3. 100 blood donors. In HIV-1 infection antiprothrombin (aPrT) antibodies were present in 25% of patients, the prevalence of antiphosphatidylcholine antibodies (aPC) (50%) was almost as high as aCL (64%), and 39% had both antibodies. Absorption on liposomes of the latter revealed an heterogeneous mixture of aCL and aPC or cross-reacting antibodies. In contrast with SLE, anti-beta 2-glycoprotein I(4%), LA (1%), biological false positive test for syphilis (0.3%), thrombosis (p <0.001) were uncommon. In HIV-1 infection, antiphospholipid antibodies do not associate with features linked to them in SLE orsyphilis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:45:22