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Titolo:
SFH1P, A COMPONENT OF A NOVEL CHROMATIN-REMODELING COMPLEX, IS REQUIRED FOR CELL-CYCLE PROGRESSION
Autore:
CAO YX; CAIRNS BR; KORNBERG RD; LAURENT BC;
Indirizzi:
SUNY HLTH SCI CTR,MORSE INST MOL BIOL & GENET,BOX 44,450 CLARKSON AVEBROOKLYN NY 11203 SUNY HLTH SCI CTR,MORSE INST MOL BIOL & GENET BROOKLYN NY 11203 SUNY HLTH SCI CTR,DEPT IMMUNOL & MICROBIOL BROOKLYN NY 11203 STANFORD UNIV,SCH MED,DEPT BIOL STRUCT STANFORD CA 94305
Titolo Testata:
Molecular and cellular biology
fascicolo: 6, volume: 17, anno: 1997,
pagine: 3323 - 3334
SICI:
0270-7306(1997)17:6<3323:SACOAN>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPSTREAM ACTIVATING SEQUENCE; YEAST SWI/SNF COMPLEX; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTIONAL ACTIVATORS; BINDING PROTEIN; MULTISUBUNIT COMPLEX; DNA SPECIFICITY; NUCLEOSOMAL DNA; NUCLEAR-PROTEIN; GENE-PRODUCTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
81
Recensione:
Indirizzi per estratti:
Citazione:
Y.X. Cao et al., "SFH1P, A COMPONENT OF A NOVEL CHROMATIN-REMODELING COMPLEX, IS REQUIRED FOR CELL-CYCLE PROGRESSION", Molecular and cellular biology, 17(6), 1997, pp. 3323-3334

Abstract

Several eukaryotic multiprotein complexes, including the Saccharomyces cerevisiae Snf/Swi complex, remodel chromatin for transcription. In contrast to the Snf/Swi proteins, Sfh1p, a new Snf5p paralog, is essential for viability. The evolutionarily conserved domain of Sfh1p is sufficient for normal function, and Sfh1p interacts functionally and physically with an essential Snf2p paralog in a novel nucleosome-restructuring complex called RSC (for remodels the structure of chromatin). A temperature-sensitive sfh1 allele arrests cells in the G(2)/M phase ofthe cell cycle, and the Sfh1 protein is specifically phosphorylated in the G(1) phase. Together, these results demonstrate a link between chromatin remodeling and progression through the cell division cycle, providing genetic clues to possible targets for RSC function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:43:45