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Titolo:
AN LPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID (AMPA) ANTAGONIST AND AN N-METHYL-D-ASPARTATE (NMDA) CHANNEL BLOCKER SYNERGISTICALLY IMPAIR SPATIAL MEMORY IN RATS
Autore:
LI HB; MATSUMOTO K; WATANABE H;
Indirizzi:
TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU ORIENTAL MED,DEPT PHARMACOL,2630 SUGITANI TOYAMA 9300194 JAPAN TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU ORIENTAL MED,DEPT PHARMACOL TOYAMA 9300194 JAPAN
Titolo Testata:
Biological & pharmaceutical bulletin
fascicolo: 11, volume: 21, anno: 1998,
pagine: 1228 - 1230
SICI:
0918-6158(1998)21:11<1228:ALA(A>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONISTS; GLUTAMATE RECEPTORS;
Keywords:
SPATIAL MEMORY; N-METHYL-D-ASPARTATE (NMDA) ANTAGONIST; LPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID (AMPA) ANTAGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
H.B. Li et al., "AN LPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID (AMPA) ANTAGONIST AND AN N-METHYL-D-ASPARTATE (NMDA) CHANNEL BLOCKER SYNERGISTICALLY IMPAIR SPATIAL MEMORY IN RATS", Biological & pharmaceutical bulletin, 21(11), 1998, pp. 1228-1230

Abstract

The interaction of the lpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonist YM90K with the competitive N-methyl-D-aspartate (NMDA) antagonist CGS19755 or with the NMDA channel blocker MK801 on the spatial memory of rats was examined by the 4-arm-baited radial maze task. When administered alone, these drugs had no effect on thespatial memory. The combination of YM90K and MK801 synergistically disrupted working and reference memories, whereas the combination of YM90K and CGS19755 had no effect. These results indicate that the blockade of the AMPA receptor and NMDA channels produces a synergistic impairment of spatial memory and suggest that interaction between the AMPA and NMDA receptors plays a role in cognitive function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:36:11