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Titolo:
DEVELOPMENT OF APPROACHES TO IMPROVE THE HEALING FOLLOWING MUSCLE CONTUSION
Autore:
KASEMKIJWATTANA C; MENETREY J; SOMOGYI G; MORELAND MS; FU FH; BURANAPANITKIT B; WATKINS SC; HUARD J;
Indirizzi:
UNIV PITTSBURGH,DEPT ORTHOPAED SURG & MOL GENET & BIOCHEM PITTSBURGH PA 15261 UNIV PITTSBURGH,MUSCULOSKELETAL RES CTR,DEPT ORTHOPAED SURG PITTSBURGH PA 15261 CHILDRENS HOSP PITTSBURGH PITTSBURGH PA 15261 UNIV PITTSBURGH,ATHLET DEPT,DIV SPORTS MED,DEPT ORTHOPAED SURG PITTSBURGH PA 15261 UNIV PITTSBURGH,DEPT PHARMACOL PITTSBURGH PA 15261 UNIV PITTSBURGH,DEPT CELL BIOL & PHYSIOL PITTSBURGH PA 15261
Titolo Testata:
Cell transplantation
fascicolo: 6, volume: 7, anno: 1998,
pagine: 585 - 598
SICI:
0963-6897(1998)7:6<585:DOATIT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; HUMAN MYOBLAST TRANSPLANTATION; REGENERATING SKELETAL-MUSCLE; ADENOVIRUS-MEDIATED TRANSFER; DUCHENNE MUSCULAR-DYSTROPHY; VIVO GENE-TRANSFER; FACTOR-I; MYOGENIC DIFFERENTIATION; QUADRICEPS CONTUSIONS; ADENOASSOCIATED VIRUS;
Keywords:
MUSCLE CONTUSION; DESMIN; VIMENTIN; GENE THERAPY; ADENOVIRUS; EX VIVO AND DIRECT GENE TRANSFER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
90
Recensione:
Indirizzi per estratti:
Citazione:
C. Kasemkijwattana et al., "DEVELOPMENT OF APPROACHES TO IMPROVE THE HEALING FOLLOWING MUSCLE CONTUSION", Cell transplantation, 7(6), 1998, pp. 585-598

Abstract

Muscle injuries are a challenging problem in traumatology, and the most frequent occurrence in sports medicine. Muscle contusions are amongthe most common muscle injuries. Although this injury is capable of healing, an incomplete functional recovery often occurs, depending on the severity of the blunt trauma. We have developed an animal model of muscle contusion in mice thigh energy blunt trauma) and characterized the muscle's ability to heal following this injury using histology andimmunohistochemistry to determine the level of muscle regeneration and the development of scar tissue, We have observed a massive muscle regeneration occurring in the first 2 wk postinjury that is subsequentlyfollowed by the development of muscle fibrosis. Based on these observations, we propose that the enhancement of muscle growth and regeneration, as well as the prevention of fibrotic development, could be used as approach(es) to improve the healing of muscle injuries. In fact, wehave identified three growth factors (bFGF, IGF-1, and NGF) capable of enhancing myoblast proliferation and differentiation in vitro and improving the healing of the injured muscle in vivo, Furthermore, the ability of adenovirus to mediate direct and ex vivo gene transfer of beta-galactosidase into the injured site opens possibilities of delivering an efficient and persistent expression of these growth factors in the injured muscle. These studies should help in the development of strategies to promote efficient muscle healing with complete functional recovery following muscle contusion. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 03:38:17