Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SEROTONIN(1B) RECEPTOR STIMULATION ENHANCES COCAINE REINFORCEMENT
Autore:
PARSONS LH; WEISS F; KOOB GF;
Indirizzi:
SCRIPPS CLIN & RES INST,DEPT NEUROPHARMACOL,DIV PSYCHOPHARMACOL,CVN-7,10550 N TORREY PINES RD LA JOLLA CA 92037
Titolo Testata:
The Journal of neuroscience
fascicolo: 23, volume: 18, anno: 1998,
pagine: 10078 - 10089
SICI:
0270-6474(1998)18:23<10078:SRSECR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE-RATIO SCHEDULE; DISCRIMINATIVE STIMULUS PROPERTIES; VENTRAL TEGMENTAL AREA; FREELY MOVING RATS; INTRAVENOUS COCAINE; NUCLEUS-ACCUMBENS; SEROTONERGIC MECHANISMS; EXTRACELLULAR DOPAMINE; SELECTIVE SEROTONIN; 5-HT(1B) RECEPTOR;
Keywords:
COCAINE; SELF-ADMINISTRATION; 5-HT1B; 5-HT1A; RU 24969; CP 94,253; CP 93,129; GR 127,935; 8-OH-DPAT; P-MPPI; PROGRESSIVE RATIO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
84
Recensione:
Indirizzi per estratti:
Citazione:
L.H. Parsons et al., "SEROTONIN(1B) RECEPTOR STIMULATION ENHANCES COCAINE REINFORCEMENT", The Journal of neuroscience, 18(23), 1998, pp. 10078-10089

Abstract

The effects of serotonin(1B) [5-hydroxytryptamine(1B) (5-HT1B)] receptor activation on cocaine reinforcement were investigated using intravenous cocaine self-administration by rats. The 5-HT1B receptor agonists methoxy-3-1,2,3,6-tetrahydro-4-pyridinyl-1H-indole (RU 24969) (0.3-3mg/kg), rahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b]pyridine (CP 94,253) (0.3-3 mg/kg), and ,2,5,6-tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyridine (CP 93,129) (3 and 10 mu g, i.c.v.) each dose-dependently reduced the self-administration of a cocaine dose on the descending limb of the fixed-ratio 5 (FR-5) cocaine dose-effect function, in a manner similarto the effect produced by increasing the unit dose of cocaine. In addition, each of these 5-HT1B agonists lowered the threshold dose of cocaine that supported self-administration. These results are consistent with a 5-HT1B agonist-induced potentiation of cocaine reinforcement. On a progressive ratio schedule of reinforcement, RU 24969 and CP 94,253 dose-dependently (0.3-3 mg/kg) increased the highest completed ratiofor cocaine self-administration, again by producing behavioral alterations similar to those induced by increasing the unit dose of cocaine. The effect of CP 94,253 was dose-dependently blocked by the 5-HT1B/1Dreceptor partial agonist 2'-methyl-4'-(5-methyl [1,2,4]oxadiazol-3-yl)-biphenyl-4-carboxylic methodoxy-3(4-methyl-piperazin-1-yl)-phenyl]-amide (GR 127,935) (0.3-10 mg/kg) but was unaffected by the 5-HT1A receptor antagonist henyl)-1-piperazinyl]ethyl]-N-2-pyridinylbenzamide (p-MPPI; 1-10 mg/kg). Self-administration behavior was not maintained when either RU 24969 or CP 94,253 was substituted for cocaine, indicatingthat these 5-HT1B agonists do not produce significant reinforcing effects alone. Together, these findings indicate that 5-HT1B receptor stimulation facilitates the reinforcing properties of cocaine. These results are in opposition to recent findings with 5-HT1B receptor knock-out mice and may have important ontogenic implications in the area of drug abuse research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:40:14