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Titolo:
CHEMOTOPIC, COMBINATORIAL, AND NONCOMBINATORIAL ODORANT REPRESENTATIONS IN THE OLFACTORY-BULB REVEALED USING A VOLTAGE-SENSITIVE AXON TRACER
Autore:
FRIEDRICH RW; KORSCHING SI;
Indirizzi:
UNIV COLOGNE,INST GENET,ZULPICHERSTR 47 D-50674 COLOGNE GERMANY UNIV COLOGNE,INST GENET D-50674 COLOGNE GERMANY MAX PLANCK INST ENTWICKLUNGSBIOL,ABT PHYS BIOL D-72076 TUBINGEN GERMANY
Titolo Testata:
The Journal of neuroscience
fascicolo: 23, volume: 18, anno: 1998,
pagine: 9977 - 9988
SICI:
0270-6474(1998)18:23<9977:CCANOR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PUTATIVE PHEROMONE RECEPTORS; MULTIGENE FAMILY; FUNCTIONAL-ORGANIZATION; SIGNAL-TRANSDUCTION; NEURONAL-ACTIVITY; F-PROSTAGLANDINS; SEX-PHEROMONES; BRAIN SLICE; BILE-ACIDS; ZEBRAFISH;
Keywords:
OLFACTORY CODING; OPTICAL RECORDING; AXON TRACING; ACTIVITY PATTERN; ZEBRAFISH; PHEROMONE; OLFACTORY GLOMERULUS; VOLTAGE-SENSITIVE DYE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
75
Recensione:
Indirizzi per estratti:
Citazione:
R.W. Friedrich e S.I. Korsching, "CHEMOTOPIC, COMBINATORIAL, AND NONCOMBINATORIAL ODORANT REPRESENTATIONS IN THE OLFACTORY-BULB REVEALED USING A VOLTAGE-SENSITIVE AXON TRACER", The Journal of neuroscience, 18(23), 1998, pp. 9977-9988

Abstract

Odor information is first represented in the brain by patterns of input activity across the glomeruli of the olfactory bulb (OB). To examine how odorants are represented at this stage of olfactory processing, we labeled anterogradely the axons of olfactory receptor neurons with the voltage-sensitive dye Di8-ANEPPQ in zebrafish. The activity induced by diverse natural odorants in afferent axons and across the array of glomeruli was then recorded optically. The results show that certainsubregions of the OB are preferentially activated by defined chemicalodorant classes. Within these subregions, ''ordinary'' odorants (amino acids, bile acids, and nucleotides) induce overlapping activity patterns involving multiple glomeruli, indicating that they are represented by combinatorial activity patterns. In contrast, two putative pheromone components (prostaglandin F-2 alpha and 17 alpha,20 beta-dihydroxy-4-pregnene-3-one-20-sulfate) each induce a single focus of activity, at least one of which comes from a single, highly specific and sensitive glomerulus. These results indicate that the OB is organized into functional subregions processing classes of odorants. Furthermore, they suggest that individual odorants can be represented by ''combinatorial'' or ''noncombinatorial'' (focal) activity patterns and that the latter may serve to process odorants triggering distinct responses such asthat of pheromones.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:42:21