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Titolo:
PSYCHOPHYSIOLOGICAL MEASURES OF (DIS)INHIBITION AS LIABILITY INDICATORS FOR SCHIZOPHRENIA
Autore:
CLEMENTZ BA;
Indirizzi:
UNIV CALIF SAN DIEGO,DEPT PSYCHOL,9500 GILMAN DR LA JOLLA CA 92093
Titolo Testata:
Psychophysiology
fascicolo: 6, volume: 35, anno: 1998,
pagine: 648 - 668
SICI:
0048-5772(1998)35:6<648:PMO(AL>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PURSUIT EYE-MOVEMENTS; AUDITORY EVOKED-RESPONSES; OBSESSIVE-COMPULSIVE DISORDER; MEMORY-GUIDED SACCADES; TRANSCRANIAL MAGNETIC STIMULATION; DORSOLATERAL PREFRONTAL CORTEX; MONKEY SUPERIOR COLLICULUS; SENSORY GATING DEFICITS; FRONTAL-LOBE LESIONS; TEMPORAL VISUAL AREA;
Keywords:
SCHIZOPHRENIA; P50 SUPPRESSION; GENETICS; NEUROPATHOLOGY; GAMMA BAND RESPONSE; SMOOTH PURSUIT; SACCADES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
227
Recensione:
Indirizzi per estratti:
Citazione:
B.A. Clementz, "PSYCHOPHYSIOLOGICAL MEASURES OF (DIS)INHIBITION AS LIABILITY INDICATORS FOR SCHIZOPHRENIA", Psychophysiology, 35(6), 1998, pp. 648-668

Abstract

Two psychophysiological measures, poor suppression of midlatency auditory-evoked responses in a paired stimulus paradigm and ocular motor abnormalities, may index genetic liability for schizophrenia. An important feature of these measures is that both patients and their nonpsychotic relatives exhibit basically the same performance. These measures may be successful endophenotypes for schizophrenia because they assesspoor response inhibition associated with dysfunction of dorsolateral prefrontal cortex circuitry. Data bearing on this hypothesis are reviewed, and it is posited that assessment of the auditory-evoked gamma band response and saccade measures of inhibitory abilities are the most valid behavioral measures of schizophrenia's neuropathological correlates. The extant data suggest that psychophysiological studies of schizophrenia can provide consistent and theoretically meaningful information for localizing neuropathology and for assessing the genetics of this complex disorder.

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Documento generato il 21/09/20 alle ore 16:06:45