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Titolo:
EXPERIMENTAL EFFECTS OF VASOACTIVE DRUGS FROM THE PHYSIOPATHOLOGICAL POINT-OF-VIEW
Autore:
SCHEFFLER A; DRIESSEN G;
Indirizzi:
LVA RHEINPROVINZ,AGGERTALKLIN,ANGIOL ABT D-51766 ENGELSKIRCHEN GERMANY LVA RHEINPROVINZ,AGGERTALKLIN,ABT NICHT INVAS DIAGNOST D-51766 ENGELSKIRCHEN GERMANY
Titolo Testata:
VASA
, , anno: 1998, supplemento:, 53
pagine: 43 - 60
SICI:
0301-1526(1998):<43:EEOVDF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
GER
Soggetto:
TUMOR-NECROSIS-FACTOR; ARTERIAL OCCLUSIVE DISEASE; BLOOD-CELL DEFORMABILITY; PERIPHERAL VASCULAR-DISEASE; SUPEROXIDE ANION PRODUCTION; HUMAN POLYMORPHONUCLEAR LEUKOCYTES; ISCHEMIA-REPERFUSION INJURY; PLATELET-ACTIVATING-FACTOR; CRITICALLY-ILL PATIENTS; FACTOR-ALPHA PRODUCTION;
Keywords:
VASOACTIVE DRUGS; BUFLOMEDIL; NAFTIDROFURYL; PENTOXIFYLLINE; CONSERVATIVE THERAPY OF PERIPHERAL ARTERIAL OCCLUSIVE DISEASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
304
Recensione:
Indirizzi per estratti:
Citazione:
A. Scheffler e G. Driessen, "EXPERIMENTAL EFFECTS OF VASOACTIVE DRUGS FROM THE PHYSIOPATHOLOGICAL POINT-OF-VIEW", VASA, 1998, pp. 43-60

Abstract

The therapeutical efficacy of the vasoactive drugs buflomedil, naftidrofuryl, and pentoxifyllin in patients with intermittent claudication seems to be pr-oven by appropriate clinical trials. However considerable uncertainty exists concerning their pharmacological modes of actionthat might be responsible for the increase in walking capacity. During the past three decades several mechanisms were studied mainly following new results of basic microcirculatory research. This paper is based on about 2500 references retrieved from the MEDLINE literature data base for the key words ''buflomedil'', ''naftidrofuryl'', and ''pentoxifyllin''. For review purposes papers were grouped according to reported effects on vascular smooth musculature, hemorheology, hemostasis, tissue metabolism, and reperfusion injury and results were checked for clinical relevance. This analysis reveals that almost all mechanisms used to explain the drug-related improvement of intermittent claudication seem to be merely speculative with the exception of their vasodilatory activity which can be demonstrated directly in patients. Furthermore, drug concentrations far above the corresponding therapeutical plasma levels were applied in a large. number of in-vitro studies and animal experiments. Especially, the frequently assumed beneficial hemorheological effects did not bear a critical analysis of underlying methodology and clinical data. This also applies to experimental results regarding protection against reperfusion injury which are contradictory and based on models not representing peripheral arterial occlusive disease. In conclusion it is suggested that according to their vasodilatoryactivity bulfomedil, naftidrofuryl, and pentoxifyllin might enhance collateral growth stimulated during exercise hyperemia by an improved recruitment of the collateral reserve.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 23:06:56