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Titolo:
CIS-ACTING INHIBITORY ELEMENTS WITHIN THE POL-ENV REGION OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-1 POSSIBLY INVOLVED IN VIRAL PERSISTENCE
Autore:
SAIGA A; ORITA S; MINOURATADA N; MAEDA M; AONO Y; ASAKAWA M; NAKAHARA K; KUBOTA R; OSAME M; IGARASHI H;
Indirizzi:
SHIONOGI INST MED SCI,2-5-1 MISHIMA OSAKA 566 JAPAN SHIONOGI INST MED SCI OSAKA 566 JAPAN KAGOSHIMA UNIV,SCH MED KAGOSHIMA 890 JAPAN
Titolo Testata:
Journal of virology
fascicolo: 6, volume: 71, anno: 1997,
pagine: 4485 - 4494
SICI:
0022-538X(1997)71:6<4485:CIEWTP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG TERMINAL REPEAT; HUMAN-IMMUNODEFICIENCY-VIRUS; BLOOD MONONUCLEAR-CELLS; I-ASSOCIATED MYELOPATHY; TROPICAL SPASTIC PARAPARESIS; PX-MESSENGER-RNA; POLYMERASE CHAIN-REACTION; CYTOTOXIC LYMPHOCYTES-T; BASAL GENE-EXPRESSION; MYB PROTEIN BINDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
A. Saiga et al., "CIS-ACTING INHIBITORY ELEMENTS WITHIN THE POL-ENV REGION OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-1 POSSIBLY INVOLVED IN VIRAL PERSISTENCE", Journal of virology, 71(6), 1997, pp. 4485-4494

Abstract

Human T-cell leukemia virus type 1 (HTLV-1) remains latent throughoutthe life of the carrier, with cells containing the provirus and viralgene expression efficiently down-regulated. On a molecular level, exactly how viruses are down-regulated in vivo remains unresolved. We described here the possibility that down-regulation results from the presence of inhibitory elements within the gag-env region of the provirus in fresh peripheral blood mononuclear cells from carriers. In vitro experiments then revealed that potent cia-acting inhibitory elements (CIEs) are indeed contained in two discrete fragments from the pol regionand weaker ones in the env region. The effect of CIEs is relieved by the HTLV-1 posttranscriptional regulator Rex through binding to the Rex-responsive element (RxRE), suggesting that Rex might interfere with pre-mRNA degradation and/or activate the export of mRNA molecules harboring both of the inhibitory elements and RxRE on the same RNA molecule. Thus, we propose the hypothesis that such functions of CIEs may be involved in HTLV-1 persistence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:55:10