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Titolo:
BIOLOGICAL-ACTIVITY OF NEW AZA ANALOGS OF QUINOLONES
Autore:
BELICOVA A; SEMAN M; MILATA V; ILAVSKY D; EBRINGER L;
Indirizzi:
COMENIUS UNIV BRATISLAVA,INST CELLULAR BIOL BRATISLAVA 81107 SLOVAKIA SLOVAK TECH UNIV,DEPT ORGAN CHEM BRATISLAVA 81237 SLOVAKIA
Titolo Testata:
Folia microbiologica
fascicolo: 3, volume: 42, anno: 1997,
pagine: 193 - 198
SICI:
0015-5632(1997)42:3<193:BONAAO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELIMINATION; AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
A. Belicova et al., "BIOLOGICAL-ACTIVITY OF NEW AZA ANALOGS OF QUINOLONES", Folia microbiologica, 42(3), 1997, pp. 193-198

Abstract

A series of novel derivatives of 4H-pyrido[1,2-a]pyrimidine, 1,4-dihydro-4-oxo-1,5-naphthyridine and 1,4-dihydro-4-oxo-1,6-naphthyridine were prepared and their biological activity was compared with that of nalidixic acid. The in vine antibacterial activity of the tested compounds was lower than that of nalidixic acid except for two agents, 1b and2c, with a higher activity against Enterococcus faecalis. The compounds were tested for their ability to cure four plasmids from two species of Enterobacteriaceae. The derivatives eliminated three plasmids (pKM101, pBR322, F'lac) at one-half or one-quarter of the minimal inhibitory concentration. Plasmid RP4 was unaffected by the treatment. None of these compounds showed better antichloroplast activity than nalidixic acid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 20:08:10