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Titolo:
SURVIVAL OF DIFFERENTIATED THYROID-CARCINOMA STUDIED IN 500 PATIENTS
Autore:
LERCH H; SCHOBER O; KUWERT T; SAUR HB;
Indirizzi:
UNIV MUNSTER,DEPT NUCL MED,ALBERT SCHWEITZER STR 33 D-48129 MUNSTER GERMANY
Titolo Testata:
Journal of clinical oncology
fascicolo: 5, volume: 15, anno: 1997,
pagine: 2067 - 2075
SICI:
0732-183X(1997)15:5<2067:SODTSI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGNOSTIC SCORING SYSTEM; LONG-TERM IMPACT; COMPLETION THYROIDECTOMY; INITIAL MANIFESTATIONS; EXTERNAL RADIOTHERAPY; FOLLOW-UP; CANCER; PAPILLARY; THERAPY; THYROGLOBULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
H. Lerch et al., "SURVIVAL OF DIFFERENTIATED THYROID-CARCINOMA STUDIED IN 500 PATIENTS", Journal of clinical oncology, 15(5), 1997, pp. 2067-2075

Abstract

Purpose: To analyze the factors that influence survival of patients with differentiated thyroid carcinoma treated by surgical thyroidectomy, radioactive iodine, and early surgical reintervention with compartment-oriented lymphadenectomy in the case of locoregionol recurrence. Methods: The survival of 500 patients with differentiated thyroid carcinoma was analyzed retrospectively with regard to mortality and survivalrare (Kaplan-Meier). A total,of 301 patients had papillary and 199 follicular thyroid carcinoma. The mean age of the 380 women and 120 men was 46.8+/-16.4 years at presentation. All patients were treated by surgical thyroidectomy, high-dose radioactive iodine, and early surgicalreintervention with compartment-oriented lymphadenectomy in cases of locoregional recurrence, without routine adjuvant external radiotherapy of the neck. patients were monitored up to 23 years, with a median followup time of 5.6 years. Results: Twenty-nine of 500 patients died, 19 of thyroid cancer. The corrected overall 5-year survival rate (Kaplan-Meier) was 0.92. Among patients with tumor stage pTl-3NO-1MO (low risk), none died of thyroid carcinoma (5-year survival rate, 0.97); in patients with tumor stage pT4 and/or M1 (high risk), the 5-year survival rate was 0.83. The cause of death was locoregional recurrence in eight and metastatic disease in 11. Using multivariate analysis, risk factors that significantly influence survival were local invasion (pT4),metastatic disease (M1), and age. Conclusion: In differentiated thyroid carcinoma, the use of total surgical thyroidectomy followed by high-dose radioiodine therapy and early surgical reintervention in case oflocoregional recurrence yields high survival rates, even without adjuvant external radiotherapy of the neck. (C) 1997 by American Society of Clinical Oncology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 23:06:38