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Titolo:
HIGH-DOSE CHEMOTHERAPY WITH AUTOLOGOUS HEMATOPOIETIC STEM-CELL SUPPORT FOR BREAST-CANCER IN NORTH-AMERICA
Autore:
ANTMAN KH; ROWLINGS PA; VAUGHAN WP; PELZ CJ; FAY JW; FIELDS KK; FREYTES CO; GALE RP; HILLNER BE; HOLLAND HK; KENNEDY MJ; KLEIN JP; LAZARUS HM; MCCARTHY PL; SAEZ R; SPITZER G; STADTMAUER EA; WILLIAMS SF; WOLFF S; SOBOCINSKI KA; ARMITAGE JO; HOROWITZ MM;
Indirizzi:
DIV MED ONCOL,MHB 6N 435,177 FT WASHINGTON AVE NEW YORK NY 10032 MED COLL WISCONSIN,HLTH POLICY INST,AUTOLOGOUS BLOOD & MARROW TRANSPLANT REGISTRY MILWAUKEE WI 53226 COLUMBIA UNIV,DIV MED ONCOL NEW YORK NY 00000 UNIV ALABAMA,DEPT MED BIRMINGHAM AL 35294 BAYLOR UNIV,MED CTR,DEPT MED DALLAS TX 00000 UNIV S FLORIDA,DEPT MED TAMPA FL 33620 UNIV TEXAS,HLTH SCI CTR,DEPT MED SAN ANTONIO TX 78284 SALICK HLTH CARE INC,DIV BONE MARROW & STEM CELL TRANSPLANTAT LOS ANGELES CA 00000 VIRGINIA COMMONWEALTH UNIV,DEPT MED RICHMOND VA 23284 EMORY CLIN,DEPT MED ATLANTA GA 30322 JOHNS HOPKINS UNIV,SCH MED,JOHNS HOPKINS ONCOL CTR,DIV MED ONCOL BALTIMORE MD 21205 MED COLL WISCONSIN,HLTH POLICY INST,DEPT BIOSTAT MILWAUKEE WI 53226 CASE WESTERN RESERVE UNIV,IRELAND CANC CTR,DEPT MED CLEVELAND OH 44106 BAYLOR COLL MED,METHODIST HOSP,DEPT MED HOUSTON TX 77030 UNIV OKLAHOMA,DEPT MED OKLAHOMA CITY OK 00000 LATTER DAY ST HOSP,DEPT MED SALT LAKE CITY UT 84143 UNIV PENN,MED CTR,DEPT MED PHILADELPHIA PA 19104 UNIV CHICAGO,HLTH SCI CTR,DEPT MED CHICAGO IL 60637 VANDERBILT UNIV,DEPT MED NASHVILLE TN 00000 UNIV NEBRASKA,DEPT MED OMAHA NE 68182
Titolo Testata:
Journal of clinical oncology
fascicolo: 5, volume: 15, anno: 1997,
pagine: 1870 - 1879
SICI:
0732-183X(1997)15:5<1870:HCWAHS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; COMPARING TOTAL MASTECTOMY; INCREASING UTILIZATION; RADICAL-MASTECTOMY; SURVIVAL; TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
K.H. Antman et al., "HIGH-DOSE CHEMOTHERAPY WITH AUTOLOGOUS HEMATOPOIETIC STEM-CELL SUPPORT FOR BREAST-CANCER IN NORTH-AMERICA", Journal of clinical oncology, 15(5), 1997, pp. 1870-1879

Abstract

Purpose: To identify trends in high-dose therapy with autologous hematopoietic stem-cell support (autotransplants) for breast cancer (1989 to 1995). Patients and Methods: Analysis of patients who received autotransplants and were reported to the Autologous Blood and Marrow Transplant Registry. Between January 1, 1989 and June 30, 1995, 19,291 autotransplants were reviewed; 5,886 were for breast cancer. Main outcomeswere progression-free survival (PFS) and survival. Results: Between 1989 and 1995, autotransplants for breast cancer increased sixfold. After 1992, breast cancer was the most common indication for autotransplant. Significant trends included increasing use for locally advanced rather than metastatic disease (P < .00001) and use of blood derived rather than marrow-derived stem cells (P < .00001). One-hundred-day mortality decreased from 22% to 5% (P < .0001). Three-year PFS probabilities were 65% (95% confidence intervals [Cls], 59 to 71)for stage 2 disease, and 60% (95% CI, 53 to 67) for stage 3 disease. In metastatic breast cancer, 3-year probabilities of PFS were 7% (95% CI, 4 to 10) for women with no response to conventional dose chemotherapy; 13% (95% CI, 9 to 17) for those with partial response; and 32% (95% CI, 27 to 37) for those with complete response. Eleven percent of women with stage 2/3 disease and less than 1% of those with stage 4 disease participated in national cooperative group randomized trials. Conclusion: Autotransplants increasingly are used to treat breast cancer. One-hundred-day mortality has decreased substantially. Three-year survival is better inwomen with earlier stage disease and in those who respond to pretransplant chemotherapy. (C) 1997 by American Society of Clinical Oncology.

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Documento generato il 05/07/20 alle ore 07:19:21