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Titolo:
EXPRESSIONS OF CCAAT ENHANCER-BINDING PROTEIN-BETA AND PROTEIN-DELTA AND THEIR ACTIVITIES ARE INTENSIFIED BY CAMP SIGNALING AS WELL AS CA2+/CALMODULIN KINASES ACTIVATION IN HIPPOCAMPAL-NEURONS/
Autore:
YUKAWA K; TANAKA T; TSUJI S; AKIRA S;
Indirizzi:
WAKAYAMA MED COLL,DEPT PHYSIOL 2,811-1 KIMIIDERA WAKAYAMA 6410012 JAPAN HYOGO MED UNIV,DEPT BIOCHEM NISHINOMIYA HYOGO 663 JAPAN
Titolo Testata:
The Journal of biological chemistry
fascicolo: 47, volume: 273, anno: 1998,
pagine: 31345 - 31351
SICI:
0021-9258(1998)273:47<31345:EOCEPA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM-MEMORY; DEPENDENT LATE-PHASE; GENE-EXPRESSION; TRANSCRIPTION FACTORS; SYNAPTIC PLASTICITY; CREB PHOSPHORYLATION; CORTICAL ASTROCYTES; RESPONSIVE ELEMENT; LEUCINE ZIPPER; C/EBP-BETA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
K. Yukawa et al., "EXPRESSIONS OF CCAAT ENHANCER-BINDING PROTEIN-BETA AND PROTEIN-DELTA AND THEIR ACTIVITIES ARE INTENSIFIED BY CAMP SIGNALING AS WELL AS CA2+/CALMODULIN KINASES ACTIVATION IN HIPPOCAMPAL-NEURONS/", The Journal of biological chemistry, 273(47), 1998, pp. 31345-31351

Abstract

The transcription factor, Aplysia CCAAT enhancer-binding protein (ApC/EBP), plays a crucial role in long term facilitation, a synaptic mechanism of long term memory in Aplysia, To gain a clue to whether the mammalian C/EBP family of transcription factors are also involved in long term memory, we examined how C/EBP activities in hippocampal neuronscan be modulated in response to cAMP and Ca2+, crucial inductive signals for memory formation. As a result, stimulation of either cAMP or Ca2+ signals in hippocampal neurons was found to enhance mRNA expressions and DNA binding activities of C/EBP beta and C/EBP delta, Furthermore, it is indicated that CaM kinases have essential roles for increasing the expression and DNA binding activities of C/EBP beta in hippocampal neurons activated by membrane depolarization. Overexpression of constitutively active calcium/calmodulin-dependent kinase TV was found to directly stimulate either C/EBP beta-dependent or C/EBP delta-dependent transcription, reinforcing the evidence that C/EBP family members contribute to Ca2+ dependent transcription. Thus, these results suggest that C/EBP beta and C/EBP delta may be involved in the transcription-dependent phase of memory formation by increasing the expression of both the DNA binding and the transcriptional activities under the direction of cAMP and/or Ca2+ signaling in hippocampal neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:45:33