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Titolo:
ALPHA-BUNGAROTOXIN-SENSITIVE AND METHYLLYCACONITINE-SENSITIVE NICOTINIC RECEPTORS MEDIATE FAST SYNAPTIC TRANSMISSION IN INTERNEURONS OF RATHIPPOCAMPAL SLICES
Autore:
ALKONDON M; PEREIRA EFR; ALBUQUERQUE EX;
Indirizzi:
UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPT THERAPEUT,655 W BALTIMOREST BALTIMORE MD 21201 UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPT THERAPEUT BALTIMORE MD 21201 UNIV FED RIO DE JANEIRO,HLTH SCI CTR,INST BIOMED SCI,DEPT BASIC & CLIN PHARMACOL BR-21944 RIO JANEIRO BRAZIL
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 810, anno: 1998,
pagine: 257 - 263
SICI:
0006-8993(1998)810:1-2<257:AAMN>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RECEPTORS; ACH RECEPTORS; NEURONS; BRAIN; DISINHIBITION; LOCALIZATION; PROJECTIONS; MODULATION; DIVERSITY; RELEASE;
Keywords:
SYNAPTIC TRANSMISSION; METHYLLYCACONITINE; NICOTINIC RECEPTOR; HIPPOCAMPUS; SLICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
M. Alkondon et al., "ALPHA-BUNGAROTOXIN-SENSITIVE AND METHYLLYCACONITINE-SENSITIVE NICOTINIC RECEPTORS MEDIATE FAST SYNAPTIC TRANSMISSION IN INTERNEURONS OF RATHIPPOCAMPAL SLICES", Brain research, 810(1-2), 1998, pp. 257-263

Abstract

This study demonstrates for the first time that alpha 7 nicotinic receptors (nAChRs) mediate fast synaptic transmission in conventional hippocampal slices. In the presence of antagonists of muscarinic, AMPA, NMDA, GABA(A), ATP, and 5-HT3 receptors, spontaneous and evoked postsynaptic currents (PSCs) recorded from CA1 interneurons were blocked by the alpha 7 nAChR antagonists methyllycaconitine and alpha-bungarotoxinand by a desensitizing concentration of the alpha 7 nAChR agonist choline. Spontaneous nicotinic PSCs were also accompanied by Na+ transients, indicating that alpha 7 nAChR-mediated transmission serves as an excitatory signal to the CA1 interneurons in the hippocampus. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:15:56