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Titolo:
A SHORT EPISODE OF SEIZURE ACTIVITY PROTECTS FROM STATUS EPILEPTICUS-INDUCED NEURONAL DAMAGE IN RAT-BRAIN
Autore:
NAJM IM; HADAM J; CKAKRAVERTY D; MIKUNI N; PENROD C; SOPA C; MARKARIAN G; LUDERS HO; BABB T; BAUDRY M;
Indirizzi:
CLEVELAND CLIN FDN,SECT EPILEPSY,DEPT NEUROL,9500 EUCLID AVE,S51 CLEVELAND OH 44195 CLEVELAND CLIN FDN,DEPT NEUROSURG CLEVELAND OH 44195 CLEVELAND CLIN FDN,DEPT NEUROSCI CLEVELAND OH 44195 UNIV SO CALIF,DEPT NEUROSCI LOS ANGELES CA 00000
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 810, anno: 1998,
pagine: 72 - 75
SICI:
0006-8993(1998)810:1-2<72:ASEOSA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
KAINIC ACID; HEAT-SHOCK; LIMBIC SEIZURES; TOLERANCE; EXPRESSION; INDUCTION; INJURY; HSP70;
Keywords:
SEIZURE; HIPPOCAMPUS; TOLERANCE; KAINATE; PENTOBARBITAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
I.M. Najm et al., "A SHORT EPISODE OF SEIZURE ACTIVITY PROTECTS FROM STATUS EPILEPTICUS-INDUCED NEURONAL DAMAGE IN RAT-BRAIN", Brain research, 810(1-2), 1998, pp. 72-75

Abstract

Kainic acid (KA)-induced status epilepticus (SE) in adult rats results in extensive neuronal damage throughout the Limbic system and the loss of selectively vulnerable neuronal populations, particularly CA3 neurons. We investigated the effects of a short episode of seizure activity on neuronal death elicited by a subsequent prolonged SE episode. Ashort episode of seizure activity was produced by sub-cutaneous (s.c.) injection of KA followed after 1 h by pentobarbital administration. Twenty-four hours later, KA was administered again, and animals were sacrificed 3 days later. Neuronal damage was estimated by visual analysis of neuronal density. Our results show that a short episode of seizure activity did not produce neuronal damage but almost completely protected vulnerable neurons from KA-induced neuronal damage. These results extend to epileptic tolerance the notion of tolerance previously described in the case of ischemia. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 03:31:06