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Titolo:
SUCCESSFUL PREIMPLANTATION GENETIC DIAGNOSIS IS RELATED TO THE NUMBEROF AVAILABLE CUMULUS-OOCYTE COMPLEXES
Autore:
VANDERVORST M; LIEBAERS I; SERMON K; STAESSEN C; DEVOS A; VANDEVELDE H; VANASSCHE E; JORIS H; VANSTEIRTEGHEM A; DEVROEY P;
Indirizzi:
FREE UNIV BRUSSELS HOSP,CTR REPROD MED,LAARBEEKLAAN 101 B-1090 BRUSSELS BELGIUM FREE UNIV BRUSSELS HOSP,CTR MED GENET B-1090 BRUSSELS BELGIUM
Titolo Testata:
Human reproduction (Oxford. Print)
fascicolo: 11, volume: 13, anno: 1998,
pagine: 3169 - 3176
SICI:
0268-1161(1998)13:11<3169:SPGDIR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACYTOPLASMIC SPERM INJECTION; IN-VITRO FERTILIZATION; POLYMERASE CHAIN-REACTION; 8-CELL MOUSE EMBRYOS; GOOD QUALITY EMBRYOS; NONOBSTRUCTIVE AZOOSPERMIA; SITU HYBRIDIZATION; ELECTIVE TRANSFER; PREGNANCY; CRYOPRESERVATION;
Keywords:
EMBRYO BIOPSY; NUMBER OF CUMULUS-OOCYTE COMPLEXES; OVARIAN STIMULATION; PREIMPLANTATION GENETIC DIAGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
M. Vandervorst et al., "SUCCESSFUL PREIMPLANTATION GENETIC DIAGNOSIS IS RELATED TO THE NUMBEROF AVAILABLE CUMULUS-OOCYTE COMPLEXES", Human reproduction (Oxford. Print), 13(11), 1998, pp. 3169-3176

Abstract

The inheritance pattern of monogenic inheritable disorders influencesthe proportion of unaffected embryos after preimplantation genetic diagnosis (PGD), We aimed to investigate the influence of the number of cumulus-oocyte complexes (COC) on the outcome after PGD, Eighty-four cycles of 47 couples were included in our analysis, All couples were atrisk of transmitting autosomal recessive, autosomal dominant, X-linked single gene disorders or sex-aneuploidies to their offspring. One PGD cycle was carried out for a Y-q-deletion of the man. The correlationbetween the numbers of COC and biopsied embryos and between the numbers of COC and unaffected embryos was highly significant (P <0.05). A pregnancy occurred in 15 cycles and a minimum of six COC were needed toachieve a pregnancy. Thirteen pregnancies were observed in cycles with at least 9 COG. The transfer rate and number of transferred embryos per cycle in the subgroups with <9 COC and greater than or equal to 9 COC were significantly higher in the latter. Although pregnancy rates did not differ significantly between the two subgroups (probably due to the low number of pregnancies), our data indicate that it is justifiable to cancel PGD cycles in which it is expected that <6 COC will be retrieved and that the couple should be informed about the poor prognosis if <9 COC are retrieved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:16:24