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Titolo:
EFFECTS OF RECRUITMENT OF COLLAPSED LUNG UNITS ON THE ELASTIC PRESSURE-VOLUME RELATIONSHIP IN ANESTHETIZED HEALTHY-ADULTS
Autore:
SVANTESSON C; SIGURDSSON S; LARSSON A; JONSON B;
Indirizzi:
UNIV LUND HOSP,DEPT CLIN PHYSIOL SE-22185 LUND SWEDEN UNIV LUND HOSP,DEPT ANAESTHESIA & INTENS CARE SE-22185 LUND SWEDEN
Titolo Testata:
Acta anaesthesiologica Scandinavica
fascicolo: 10, volume: 42, anno: 1998,
pagine: 1149 - 1156
SICI:
0001-5172(1998)42:10<1149:EOROCL>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; END-EXPIRATORY PRESSURE; MECHANICAL VENTILATION; GENERAL-ANESTHESIA; TIDAL VOLUME; CHEST-WALL; PULMONARY; DISEASE; RABBITS; FAILURE;
Keywords:
COMPLIANCE; HUMAN; MECHANICAL VENTILATION; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
C. Svantesson et al., "EFFECTS OF RECRUITMENT OF COLLAPSED LUNG UNITS ON THE ELASTIC PRESSURE-VOLUME RELATIONSHIP IN ANESTHETIZED HEALTHY-ADULTS", Acta anaesthesiologica Scandinavica, 42(10), 1998, pp. 1149-1156

Abstract

Background: The elastic pressure-volume (P-el-V) curve of the respiratory system can be used as a guide for improved ventilator management. The understanding of curves recorded for sick patients can be improved with better knowledge of the P-el-V relationship observed in healthyhumans. Dynamic P-el-V curves were determined over an extended volumerange in 15 anaesthetised and muscle-relaxed healthy humans. The influence of a recruitment manoeuvre was studied. Methods: Dynamic P-el-V curves were determined during a single prolonged insufflation before and after the recruitment manoeuvre. A mathematical three-segment modelof the curve including a linear intermediate segment, delineated by the lower (LIP) and upper (UIP) inflection points, was used for characterisation of the recorded curves. Results: The model gave an adequate description of the recorded P-el-V curves. Before the recruitment manoeuvre, compliance increased until the LIP was reached at 20 cm H2O (1.9 L). Then followed a long linear segment. After the recruitment manoeuvre, compliance increased during insufflation until a LIP was reachedat 13 cm H2O (1.2 L). Above the LIP followed a shorter linear segment(compliance=140 mL/cm H2O) and then an upper segment with decreasing compliance. Conclusion: P-el-V curves recorded before and after the recruitment manoeuvre show that large lung compartments close during anaesthesia and that high pressures are needed to achieve recruitment even in the normal lung. Accordingly, the LIP does not define the end of recruitment during insufflation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:37:27