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Titolo:
COMPARISON OF VEGF, VEGF-B, VEGF-C AND ANG-1 MESSENGER-RNA REGULATIONBY SERUM, GROWTH-FACTORS, ONCOPROTEINS AND HYPOXIA
Autore:
ENHOLM B; PAAVONEN K; RISTIMAKI A; KUMAR V; GUNJI Y; KLEFSTROM J; KIVINEN L; LAIHO M; OLOFSSON B; JOUKOV V; ERIKSSON U; ALITALO K;
Indirizzi:
UNIV HELSINKI,HAARTMAN INST,MOL CANC BIOL LAB,PL21 HAARTMANINKATU 3 FIN-00014 HELSINKI FINLAND UNIV HELSINKI,HAARTMAN INST,MOL CANC BIOL LAB FIN-00014 HELSINKI FINLAND UNIV HELSINKI,HAARTMAN INST,DEPT VIROL FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT CLIN CHEM HELSINKI 00290 FINLAND UNIV HELSINKI,DEPT OBSTET & GYNECOL HELSINKI 00290 FINLAND LUDWIG INST CANC RES S-17177 STOCKHOLM SWEDEN
Titolo Testata:
Oncogene
fascicolo: 20, volume: 14, anno: 1997,
pagine: 2475 - 2483
SICI:
0950-9232(1997)14:20<2475:COVVVA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR-PERMEABILITY FACTOR; FACTOR GENE-EXPRESSION; PROTEIN-KINASE-C; INDUCED TRANSCRIPTION; EPITHELIAL-CELLS; TYROSINE KINASE; MESSENGER-RNA; HA-RAS; P53; ANGIOGENESIS;
Keywords:
VEGF; VEGF-B; VEGF-C; ANGIOPOIETIN; ANGIOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
B. Enholm et al., "COMPARISON OF VEGF, VEGF-B, VEGF-C AND ANG-1 MESSENGER-RNA REGULATIONBY SERUM, GROWTH-FACTORS, ONCOPROTEINS AND HYPOXIA", Oncogene, 14(20), 1997, pp. 2475-2483

Abstract

The vascular endothelial growth factor (VEGF) family has recently been expanded by the isolation of two additional growth factors, VEGF-B and VEGF-C, Here we compare the regulation of steady-state levels of VEGF, VEGF-B and VEGF-C mRNAs in cultured cells by a variety of stimuli implicated in angiogenesis and endothelial cell physiology, Hypoxia, Ras oncoprotein and mutant p53 tumor suppressor, which are potent inducers of VEGF mRNA did not increase VEGF-B or VEGF-C mRNA levels. Serum and its component growth factors, platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) as well as transforming growth factor-beta (TGF-beta) and the tumor promoter phorbol myristate 12,13-acetate (PMA) stimulated VEGF-C, but not VEGF-B mRNA expression, Interestingly, these growth factors and hypoxia simultaneously downregulated the mRNA of another endothelial cell specific ligand, angiopoietin-1. Serum induction of VEGF-C mRNA occurred independently of protein synthesis; with an increase of the mRNA half-life from 3.5 h to 5.5-6 h, whereas VEGF-B mRNA was very stable (T-1/2>8h). Our results reveal that the three VEGF genes are regulated in a strikingly different manner, suggesting that they serve distinct, although perhaps overlapping functions in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:15:09