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Titolo:
THE ROLE OF THE HEPATIC CYTOCHROME-P450 ENZYMES IN PSYCHOPHARMACOLOGY
Autore:
NORMANN C; HESSLINGER B; BAUER J; BERGER M; WALDEN J;
Indirizzi:
UNIV FREIBURG,KLIN PSYCHIAT & PSYCHOSOMAT,ABT PSYCHIAT & PSYCHOTHERAPIE,HAUPTSTR 5 D-79104 FREIBURG GERMANY UNIV FREIBURG KLINIKUM,KLIN PSYCHIAT & PSYCHOSOMAT,ABT PSYCHIAT & PSYCHOTHERAPIE FREIBURG GERMANY
Titolo Testata:
Nervenarzt
fascicolo: 11, volume: 69, anno: 1998,
pagine: 944 - 955
SICI:
0028-2804(1998)69:11<944:TROTHC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
GER
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; HUMAN LIVER-MICROSOMES; CARBAMAZEPINE-INDUCED REDUCTION; STATE PLASMA-CONCENTRATIONS; DRUG-INTERACTIONS; POOR METABOLIZERS; IN-VITRO; N-DEMETHYLATION; VALPROIC ACID; CYP2D6 GENE;
Keywords:
CYTOCHROME P450; PHARMACOKINETICS; SELECTIVE SEROTONIN REUPTAKE INHIBITORS; GENETIC POLYMORPHISM; DRUG INTERACTIONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
145
Recensione:
Indirizzi per estratti:
Citazione:
C. Normann et al., "THE ROLE OF THE HEPATIC CYTOCHROME-P450 ENZYMES IN PSYCHOPHARMACOLOGY", Nervenarzt, 69(11), 1998, pp. 944-955

Abstract

Nearly all psychotropic drugs are metabolized by hepatic cytochrome P450-enzymes. In humans,there are 5 isoenzymes involved in this process. The activity of these enzymes can be modulated by a number of commonly used drugs,yielding potentially hazardous interactions. Most of therecently introduced selective serotonin reuptake inhibitors are potent inhibitors of cytochrome P450 enzymes. Thus, the plasma concentrations of tricyclic antidepressants or clozapine might be elevated into toxic levels. In contrast, carbamazepine induces most of the isoenzymes. This potentiates the elimination of tricyclics and antipsychotics andmight cause a serious risk for the reccurence of depressive or psychotic symptoms. Moreover, 5-10% of the population are slow metabolizers of CYP2D6. This group is prone to increased adverse effects of moderately dosed medication. This review systematically points out the reported or predicted pharmacokinetic drug interactions in psychopharmacology focussing on clinical significance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:14:05