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Titolo:
THE GENETICS OF INHERITED BREAST-CANCER
Autore:
GAYTHER SA; PHAROAH PDP; PONDER BAJ;
Indirizzi:
ADDENBROOKES HOSP,CRC,HUMAN CANC GENET RES GRP,HILLS RD CAMBRIDGE ENGLAND
Titolo Testata:
Journal of mammary gland biology and neoplasia
fascicolo: 4, volume: 3, anno: 1998,
pagine: 365 - 376
SICI:
1083-3021(1998)3:4<365:TGOIB>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
EARLY-ONSET BREAST; LINE BRCA1 MUTATIONS; OVARIAN-CANCER; GERMLINE MUTATIONS; SUSCEPTIBILITY GENE; JEWISH WOMEN; ATAXIA-TELANGIECTASIA; AMERICAN FAMILIES; HEREDITARY BREAST; CARRIER FREQUENCY;
Keywords:
GENETICS; BRCA1; BRCA2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
86
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Gayther et al., "THE GENETICS OF INHERITED BREAST-CANCER", Journal of mammary gland biology and neoplasia, 3(4), 1998, pp. 365-376

Abstract

The isolation of BRCA1 and BRCA2 has greatly increased our understanding of the genetics of inherited breast and ovarian cancer although the functions of these genes are not yet fully understood. We will discuss the current state of knowledge about the function of BRCA1 and BRCA2 and summarize the cancer risks in women carrying a BRCA1 or BRCA2 mutation. We review the evidence for gene-gene and gene-environment interaction in modifying that risk, and discuss the contribution of BRCA1 and BRCA2 and other high penetrance genes to both inherited and sporadic breast cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 16:23:41