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Titolo:
CLONING AND FUNCTIONAL-CHARACTERIZATION OF THE MOUSE P2X(7) RECEPTOR
Autore:
CHESSELL IP; SIMON J; HIBELL AD; MICHEL AD; BARNARD EA; HUMPHREY PPA;
Indirizzi:
UNIV CAMBRIDGE,DEPT PHARMACOL,GLAXO INST APPL PHARMACOL,TENNIS COURT RD CAMBRIDGE CB2 1QJ ENGLAND ROYAL FREE HOSP,MOL NEUROBIOL UNIT LONDON NW3 2QG ENGLAND
Titolo Testata:
FEBS letters
fascicolo: 1-2, volume: 439, anno: 1998,
pagine: 26 - 30
SICI:
0014-5793(1998)439:1-2<26:CAFOTM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NTW8 MICROGLIAL CELLS; P-2X RECEPTOR; PATCH-CLAMP; PURINOCEPTOR;
Keywords:
MOUSE P2X(7) RECEPTOR; P2Z RECEPTOR; ATP; PORE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
I.P. Chessell et al., "CLONING AND FUNCTIONAL-CHARACTERIZATION OF THE MOUSE P2X(7) RECEPTOR", FEBS letters, 439(1-2), 1998, pp. 26-30

Abstract

We have isolated a 1785-bp complementary DNA (cDNA) encoding the murine P2X(7) receptor subunit from NTW8 mouse microglial cells. The encoded protein has 80% and 85% homology to the human and rat P2X(7) subunits, respectively. Functional properties of the heterologously expressed murine P2X(7) homomeric receptor broadly resembled those of the P2X(7) receptor in the native cell line. However, marked phenotypic differences were observed between the mouse receptor, and the other P2X(7) receptor orthologues isolated with respect to agonist and antagonist potencies, and the kinetics of formation of the large aqueous pore. (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:48:52