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Titolo:
DIFFERENTIAL LOCALIZATION OF G-PROTEINS, G-ALPHA-O AND G-ALPHA-I-1, G-ALPHA-I-2, AND G-ALPHA-I-3, IN POLARIZED EPITHELIAL MDCK CELLS
Autore:
HAMILTON SE; NATHANSON NM;
Indirizzi:
UNIV WASHINGTON,SCH MED,DEPT PHARMACOL SEATTLE WA 98195
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 1, volume: 234, anno: 1997,
pagine: 1 - 7
SICI:
0006-291X(1997)234:1<1:DLOGGA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANINE KIDNEY-CELLS; GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; RECEPTOR; SUBUNITS; G(O); INHIBITION; EXPRESSION; CLONING; ELEGANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
S.E. Hamilton e N.M. Nathanson, "DIFFERENTIAL LOCALIZATION OF G-PROTEINS, G-ALPHA-O AND G-ALPHA-I-1, G-ALPHA-I-2, AND G-ALPHA-I-3, IN POLARIZED EPITHELIAL MDCK CELLS", Biochemical and biophysical research communications, 234(1), 1997, pp. 1-7

Abstract

MDCK cells were stably transfected with rat G alpha o cDNA and confluent polarized monolayers were analyzed by immunocytochemistry to compare the intracellular targeting of G alpha o with the localization of the endogenously expressed G alpha i subunits. Immunofluorescence confocal microscopy showed that G alpha o is targeted strictly to the lateral membrane. Immunolocalization of G alpha i-1, -2, and -3 showed thatG alpha i-1 and -2 are confined to the cytoplasm and G alpha i-3 is found on the lateral membrane, in the cytoplasm, and faintly on the apical surface of these cells. Thus, the different pertussis toxin-sensitive G-proteins are differentially localized in polarized epithelial cells. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 06:48:14