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Titolo:
LACK OF EFFECT OF FOOD ON THE BIOAVAILABILITY OF ORAL AZITHROMYCIN TABLETS
Autore:
SIMICEVIC VN; ERCEG D; DOHOCZKY C; RADOSEVIC S; SPAVENTI R; BURAGLIO M; CANALI S; CULIG J;
Indirizzi:
PLIVA RES INST,DEPT MED,PRILAZ BARUNA FILIPOVICA 25 HR-10000 ZAGREB CROATIA LCG BIOSCI,CLIN PHARMACOL UNIT CAMBRIDGE ENGLAND LCG BIOSCI RBM,INST RIC BIOMED,PHARMACOKINET & METAB UNIT TURIN ITALY PLIVA DD,DIV PHARMACEUT ZAGREB CROATIA
Titolo Testata:
Clinical drug investigation
fascicolo: 5, volume: 16, anno: 1998,
pagine: 405 - 410
SICI:
1173-2563(1998)16:5<405:LOEOFO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHARMACOKINETICS; ABSORPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
V.N. Simicevic et al., "LACK OF EFFECT OF FOOD ON THE BIOAVAILABILITY OF ORAL AZITHROMYCIN TABLETS", Clinical drug investigation, 16(5), 1998, pp. 405-410

Abstract

Objective: The purpose of this study was to assess the effect of foodon the bioavailability of an oral azithromycin formulation (Sumamed(R) tablets, Pliva, Zagreb, Croatia). Patients and Methods: Azithromycinwas administered as a single oral dose of 500mg (one tablet) to 28 male and female volunteers either in fasting conditions or immediately after a standard high fat breakfast. The study design was single-centre, open, randomised, single-dose, two-period, food and fasting crossover, with a washout between the study periods of 3 weeks. Results: Fed volunteers demonstrated a mean maximum plasma concentration (C-max) about 19% higher than fasting volunteers, but this difference was not statistically significant. Similarly, fed volunteers showed an area underthe plasma concentration-time curve about 14% higher than fasting volunteers, which was not statistically different. A statistically significant difference was noted in median time to reach C-max values between the two groups. However, this finding cannot be considered to be of great importance since the clinical use of azithromycin is not based on its rapid release or action. Conclusion: Administration of azithromycin with a high fat meal did not significantly modify the bioavailability of the 500mg tablet formulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:24:59