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Titolo:
3-DIMENSIONAL AND ULTRASTRUCTURAL ASPECTS OF THE LYMPHATIC VASCULARIZATION OF THE VERMIFORM APPENDIX
Autore:
AZZALI G;
Indirizzi:
UNIV PARMA,IST ANAT UMANA,FAC MED,VIA GRAMSCI 14 I-43100 PARMA ITALY
Titolo Testata:
Journal of submicroscopic cytology and pathology
fascicolo: 4, volume: 30, anno: 1998,
pagine: 545 - 553
SICI:
1122-9497(1998)30:4<545:3AUAOT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-ENDOTHELIAL VENULES; RAT PEYERS-PATCHES; LYMPHOCYTE MIGRATION; RABBIT APPENDIX; BLOOD-VESSELS; ORGANIZATION; TRICHINOSIS; ELECTRON; NODES;
Keywords:
VERMIFORM APPENDIX; LYMPH AND BLOOD VESSELS; LYMPHOCYTES; TRANSENDOTHELIAL MIGRATION; ULTRASTRUCTURE; 3-DIMENSIONAL MODELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
G. Azzali, "3-DIMENSIONAL AND ULTRASTRUCTURAL ASPECTS OF THE LYMPHATIC VASCULARIZATION OF THE VERMIFORM APPENDIX", Journal of submicroscopic cytology and pathology, 30(4), 1998, pp. 545-553

Abstract

The aim of the study is to reveal the three-dimensional distribution and ultrastructure of the peripheral absorbing lymphatic vessels of the vermiform appendix, since the gut-associated lymphoid tissue is necessary to the immune responses to the enteric antigens. Corrosion castsshowed the beginning of the lymphatic vascularization at the tunica mucosa, which lacks intestinal villi, through a tight, delicate lymphatic network. This network drains the lymph by peculiar straight vessels, distributed in the mucosal beams that separate the adjacent follicledomes, in the fine network of the upper portion of the lymphatic basket, surrounding the lateral walls of the basal and medium portions of each lymphoid follicle. This network, which is made of large caliber vessels that are not dilated like sinuses, continues through small vessels into the large dome-like vessels of the submucosa, which in turn by way of the lymphatic vessels of the muscular tunica, drain into the subserous precollector valved lymphatic vessels that flow into the pre-lymph node collectors. We underlined that the particular fluidity of Neoprene latex and the direct injection method, when compared with other substances and injection methods, provided us with exceptionally clear and precise three-dimensional plastic images of the absorbing lymphatic vessels. Moreover, these images extraordinarily illustrated the preservation of the absorbing lymphatic spatial relationships with blood vessels. Ultrastructural features and three-dimensional models of ultrathin serial sections of the absorbing peripheral lymphatic vesselsshowed a continuous endothelial wall lacking basal lamina, as well asopen junctions between adjacent cells. Moreover, we observed the presence of numerous lymphocytes, together with intense transendothelial migratory activity that occurs through intraendothelial channel formations, dynamic entities, at absorbing lymphatic vessels of the peri-interfollicular lymphoid tissue. Also, we saw that the germinal center, aswell as the lymphoid follicle dome, lacked lymphatic absorbing vessels. In addition, many postcapillary high endothelial venules (HEV) wereobserved with lymphocyte migration into the extravasal compartment. Furthermore, we maintain that the absorbing peripheral lymphatic vessels (ALPA) of the tunica mucosa play an important role in liquid drainage. For the peri-interfollicular vessels, we hypothesize a potential migratory and a reserve capacity for lymphocytes, as well as a conduction activity for the muscular tunica and submucosa vessels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:30:07