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Titolo:
EXPRESSION OF THE E-CADHERIN-CATENIN CELL-ADHESION COMPLEX IN PRIMARYSQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK AND THEIR NODAL METASTASES
Autore:
ANDREWS NA; JONES AS; HELLIWELL TR; KINSELLA AR;
Indirizzi:
UNIV LIVERPOOL,DEPT SURG,CELLULAR ONCOL GRP,POB 147 LIVERPOOL L69 3BXMERSEYSIDE ENGLAND UNIV LIVERPOOL,DEPT SURG,CELLULAR ONCOL GRP LIVERPOOL L69 3BX MERSEYSIDE ENGLAND UNIV LIVERPOOL,DEPT OTORHINOLARYNGOL LIVERPOOL L69 3BX MERSEYSIDE ENGLAND UNIV LIVERPOOL,DEPT PATHOL LIVERPOOL L69 3BX MERSEYSIDE ENGLAND
Titolo Testata:
British Journal of Cancer
fascicolo: 10, volume: 75, anno: 1997,
pagine: 1474 - 1480
SICI:
0007-0920(1997)75:10<1474:EOTECC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULE E-CADHERIN; ALPHA-CATENIN; BETA-CATENIN; LYMPH-NODE; PROSTATE-CANCER; GASTRIC-CANCER; LARGE-BOWEL; HIGH-GRADE; LINES; DEDIFFERENTIATION;
Keywords:
SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK; CELL ADHESION; E-CADHERIN COMPLEX; METASTASIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
N.A. Andrews et al., "EXPRESSION OF THE E-CADHERIN-CATENIN CELL-ADHESION COMPLEX IN PRIMARYSQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK AND THEIR NODAL METASTASES", British Journal of Cancer, 75(10), 1997, pp. 1474-1480

Abstract

Reductions in cell-cell adhesion and stromal and vascular invasion are essential steps in the progression from localized malignancy to metastatic disease. In this study, changes in the expression of the components of the E-cadherin-catenin cell adhesion complex have been investigated using immunohistochemical techniques in primary tumours and nodal metastases from 36 patients with squamous cell carcinoma of the headand neck. For 14 patients the corresponding primary and nodal metastases samples were available. None of the 51 samples showed normal E-cadherin expression when compared with either the adjacent normal squamous epithelium or with normal colonic epithelium that was used as positive control material. In 88% of primary tumours fewer than 50% of cellsexhibited normal membranous E-cadherin expression. Loss of membranousE-cadherin expression was more extensive in poorly differentiated carcinomas while, in individual carcinomas, membranous E-cadherin expression was stronger in those parts of the neoplasm that expressed the differentiation marker involucrin, Expression of beta-catenin generally paralleled that of E-cadherin, but in 12 cases there was strong membranous beta-catenin expression in samples that exhibited predominantly cytoplasmic E-cadherin labelling. Expression of alpha-catenin was generally weak and did not correlate with the expression of either beta-catenin or E-cadherin. Marked intratumoral heterogeneity for protein expression was evident for all antibodies, and the abnormal expression of the catenins is a novel finding, E-cadherin is expressed more intenselyin cells with greater squamous differentiation, but there was no correlation between the decreased expression of any of the adhesion molecules of the E-cadherin complex tested and local recurrence, metastasis or survival. The loss of expression of components of the E-cadherin complex is a common abnormality in squamous carcinomas and, while it maybe permissive for metastasis, it does not appear to be the only determinant of this process.

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Documento generato il 15/07/20 alle ore 14:26:31