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Titolo:
NUCLEOTIDE-SEQUENCE AND TRANSCRIPTION MAP OF PORCINE ADENOVIRUS TYPE-3
Autore:
REDDY PS; IDAMAKANTI N; SONG JY; LEE JB; HYUN BH; PARK JH; CHA SH; BAE YT; TIKOO SK; BABIUK LA;
Indirizzi:
UNIV SASKATCHEWAN,VET INFECT DIS ORG,120 VET RD SASKATOON SK S7N 5E3 CANADA NATL VET RES INST KYONGGI DO SOUTH KOREA KON KUK UNIV,LAB VET MICROBIOL,KWANJIN GU SEOUL SOUTH KOREA
Titolo Testata:
Virology (New York, N.Y. Print)
fascicolo: 2, volume: 251, anno: 1998,
pagine: 414 - 426
SICI:
0042-6822(1998)251:2<414:NATMOP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING PROTEIN; L4 100-KILODALTON PROTEIN; AMINO-ACID-SEQUENCE; MAJOR LATE PROMOTER; LATE MESSENGER-RNA; NUCLEAR-LOCALIZATION; PRETERMINAL PROTEIN; OVINE ADENOVIRUS; POLYMERASE-ALPHA; PENTON BASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
85
Recensione:
Indirizzi per estratti:
Citazione:
P.S. Reddy et al., "NUCLEOTIDE-SEQUENCE AND TRANSCRIPTION MAP OF PORCINE ADENOVIRUS TYPE-3", Virology (New York, N.Y. Print), 251(2), 1998, pp. 414-426

Abstract

The complete nucleotide sequence of porcine adenovirus type 3 was determined and a transcriptional map for the genome was constructed. The size of the genome is 34094 bp in length with an unusually high G + C content (63.7%), the highest thus far reported for any adenovirus. Overall organization of the genome is similar to that for previously sequenced adenoviral DNAs, but there also were distinct differences. The late regions genes are organized into six families, instead of five as they are in human adenovirus type 2. In contrast to bovine adenovirus type 3 and ovine adenovirus, which lack virion-associated RNA genes, the nucleotide sequence analysis of the viral genome indicates that it encodes one short VA RNA species. With the exception of the fiber and a 33-kDa nonstructural protein, the predicted amino acid sequences of the open reading frames in the late regions and the E2 region and IVa2exhibited a high level of homology, whereas the deduced amino acid sequences of ORFs in E1, E3, and E4 regions, and the pIX showed a lesserhomology with the corresponding proteins of other adenoviruses. The proteins V, VII, and IX are unusually long, and the protein VII lacks the consensus protease cleavage site. Genomic and cDNA sequence analysis has identified promoters, cap sites, intron-exon boundaries, polyadenylation signals, and polyadenylation sites in the viral genome. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 00:01:32