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Titolo:
THE EFFECT OF ENDOTOXIN ON IN-VIVO RAT ALVEOLAR MACROPHAGE PHAGOCYTOSIS
Autore:
FREVERT CW; WARNER AE; WELLER E; BRAIN JD;
Indirizzi:
SEATTLE VAMC,PULM RES GRP,1660 S COLUMBIAN WAY,151L SEATTLE WA 98108 HARVARD UNIV,SCH PUBL HLTH,PHYSIOL PROGRAM BOSTON MA 02115 UNIV WASHINGTON,DIV PULM & CRIT CARE MED SEATTLE WA 00000 HARVARD UNIV,SCH MED,ARC BOSTON MA 00000 HARVARD UNIV,SCH PUBL HLTH,DEPT BIOSTAT BOSTON MA 00000
Titolo Testata:
Experimental lung research
fascicolo: 6, volume: 24, anno: 1998,
pagine: 745 - 758
SICI:
0190-2148(1998)24:6<745:TEOEOI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; PULMONARY INTRAVASCULAR MACROPHAGES; HUMAN MONOCYTE-MACROPHAGES; LUNG INJURY; BACTERIAL CLEARANCE; CANINE MODEL; LIPOPOLYSACCHARIDE; SHEEP; PNEUMONIA; MORTALITY;
Keywords:
ALVEOLAR MACROPHAGE; ENDOTOXIN; HOST DEFENSES; LIPOPOLYSACCHARIDES; LUNGS; NEUTROPHILS; PHAGOCYTOSIS; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
C.W. Frevert et al., "THE EFFECT OF ENDOTOXIN ON IN-VIVO RAT ALVEOLAR MACROPHAGE PHAGOCYTOSIS", Experimental lung research, 24(6), 1998, pp. 745-758

Abstract

This study was performed to explore whether alveolar macrophage (AM) phagocytosis would be impaired during endotoxemia. Therefore, we characterized in vivo AM phagocytic function in rats following either intravenous (IV) or intratracheal (IT) administration of lipopolysaccharide(LPS). The IV administration of LPS to rats at dosages of 0, 1, 2, and 5 mg/kg showed that increasing LPS doses were significantly associated with ino eased AM phagocytosis of Au-198 colloid (P < .01), decreased recovery of AMs in bronchoalveolar lavage (BAL) (P = .017), no significant differences in neutrophil recovery by lavage (P = .15), or in the concentration of albumin in BAL (P = .14). Across the dosages of LPS administered IT (i.e., 0, 1, 5, and 10 mg/kg), there was no difference in AM phagocytosis (P = .29), a significant decrease in AM recovery (P = .002), a significant increase in neutrophil number (P = .01), and little effect on the concentration of albumin (P = .06). Thus, we found that the administration of endotoxin to mis did not impair in vivo AM phagocytic function. In fact, our findings suggest that the IV administration of LPS mar increase AM phagocytosis of Au-198.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 11:30:24