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Titolo:
REDUCED BRAIN-SEROTONIN TRANSPORTER AVAILABILITY IN MAJOR DEPRESSION AS MEASURED BY [I-123] 2-BETA-CARBOMETHOXY-3-BETA-(4-IODOPHENYL)TROPANE AND SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY
Autore:
MALISON RT; PRICE LH; BERMAN R; VANDYCK CH; PELTON GH; CARPENTER L; SANACORA G; OWENS MJ; NEMEROFF CB; RAJEEVAN N; BALDWIN RM; SEIBYL JP; INNIS RB; CHARNEY DS;
Indirizzi:
CONNECTICUT MENTAL HLTH CTR,ABRAHAM RIBICOFF RES FACIL,CLIN NEUROSCI RES UNIT,34 PK ST NEW HAVEN CT 06519 YALE UNIV,SCH MED,DEPT PSYCHIAT NEW HAVEN CT 06510 YALE UNIV,SCH MED,DEPT DIAGNOST RADIOL NEW HAVEN CT 06510 VET AFFAIRS MED CTR W HAVEN CT 00000 BROWN UNIV,BUTLER HOSP,DEPT PSYCHIAT & HUMAN BEHAV,SCH MED PROVIDENCERI 02906 EMORY UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI ATLANTA GA 30322
Titolo Testata:
Biological psychiatry
fascicolo: 11, volume: 44, anno: 1998,
pagine: 1090 - 1098
SICI:
0006-3223(1998)44:11<1090:RBTAIM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; IN-VITRO BINDING; I-123 BETA-CIT; UPTAKE SITES; IMIPRAMINE BINDING; NONHUMAN-PRIMATES; DOPAMINE TRANSPORTERS; ENDOGENOUS DOPAMINE; RAT-BRAIN; INVIVO;
Keywords:
MAJOR DEPRESSION; SPECT; [I-123] BETA-CIT; PAROXETINE; SEROTONIN TRANSPORTER PLATELETS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
R.T. Malison et al., "REDUCED BRAIN-SEROTONIN TRANSPORTER AVAILABILITY IN MAJOR DEPRESSION AS MEASURED BY [I-123] 2-BETA-CARBOMETHOXY-3-BETA-(4-IODOPHENYL)TROPANE AND SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY", Biological psychiatry, 44(11), 1998, pp. 1090-1098

Abstract

Background: Prior research has suggested reductions in the density ofserotonin transporter (SERT) binding sites in blood platelets and post-mortem brain tissue of depressed patients. We sought to determine whether patients with unipolar major depression have diminished SERT availability as assessed by both brainstem [I-123]beta-CIT SPECT and platelet [H-3]paroxetine binding. Methods: Drug-free depressed and healthysubjects were injected with 211 +/- 22 MBq [I-123]beta-CIT mid imaged24 +/- 2 h later under equilibrium conditions. A ratio of specific tononspecific brain uptake (V-3'' = (brainstem-occipital)/occipital), ameasure proportional to the binding potential (B-max/K-d), was used for all comparisons. Results: Results showed a statistically significant reduction in brainstem V-3'' values in depressed as compared to healthy subjects (3.1 +/- .9 vs. 3.8 +/- .8, p = .02). Platelet [H-3]paroxetine binding was nor altered (B-max = 2389 +/- 484 vs. 2415 +/- 538 fmol/mg protein, p = .91) and was not significantly correlated with brainstem [I-123]beta-CIT binding (r = -0.14, p = .48). Conclusions: These data are rite first to suggest reductions in the density of brain SERT binning sires in living depressed patients. These findings provide further support for a preeminent role for alterations in serotonergic neurons in the pathophysiology of depression. (C) 1998 Society of Biological Psychiatry.

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Documento generato il 25/01/20 alle ore 19:29:49