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Titolo:
PLASMA METHADONE CONCENTRATIONS AS AN INDICATOR OF OPIOID WITHDRAWAL SYMPTOMS AND HEROIN USE IN A METHADONE-MAINTENANCE PROGRAM
Autore:
TORRENS M; CASTILLO C; SAN L; DELMORAL E; GONZALEZ ML; DELATORRE R;
Indirizzi:
UNIV AUTONOMA BARCELONA,HOSP MAR,SERVEI PSIQUIATRIA,PASSEIG MARITIM 25-29 E-08003 BARCELONA SPAIN INST MUNICIPAL INVEST MED,DEPT PHARMACOL E-08003 BARCELONA SPAIN
Titolo Testata:
Drug and alcohol dependence
fascicolo: 3, volume: 52, anno: 1998,
pagine: 193 - 200
SICI:
0376-8716(1998)52:3<193:PMCAAI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN IMMUNODEFICIENCY VIRUS; DRUG-USE; MANAGEMENT; ABUSE; RISK;
Keywords:
PLASMA METHADONE CONCENTRATIONS; PLASMA EDDP CONCENTRATIONS; METHADONE MAINTENANCE; OPIOID WITHDRAWAL SYMPTOMS; HEROIN USE; COCAINE USE; TREATMENT COMPLIANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M. Torrens et al., "PLASMA METHADONE CONCENTRATIONS AS AN INDICATOR OF OPIOID WITHDRAWAL SYMPTOMS AND HEROIN USE IN A METHADONE-MAINTENANCE PROGRAM", Drug and alcohol dependence, 52(3), 1998, pp. 193-200

Abstract

Plasma methadone concentrations and its main metabolite 2-ethylidiene-1,5-dimethyl-3,5-diphenylpyrrolidine (EDDP) were determined in 93 patients under methadone maintenance treatment to assess their relationship with heroin use and opioid withdrawal symptoms. Neither plasma concentrations of methadone nor EDDP were significantly different when patients that used heroin in last 3 months were compared with those testing negative for this drug (methadone, 355 +/- 217 versus 369 +/- 216 ng/ml, t = 0.29, P = NS; EDDP, 49 +/- 28 versus 54 +/- 40 ng/ml, t = 0.51, P = NS). No correlation between opioid withdrawal scale scores andplasma concentrations of methadone (r = 0.02, P = NS) and EDDP (r = -0.14, P = NS) was found. Therapeutic drug monitoring during methadonemaintenance seems to be useful for assessing compliance with treatment but not for predicting heroin use and subjective withdrawal symptoms. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 04:27:42