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Titolo:
DIETARY AND NUTRITIONAL FACTORS AND PANCREATIC-CANCER - A CASE-CONTROL STUDY BASED ON DIRECT INTERVIEWS
Autore:
SILVERMAN DT; SWANSON CA; GRIDLEY G; WACHOLDER S; GREENBERG RS; BROWN LM; HAYES RB; SWANSON GM; SCHOENBERG JB; POTTERN LM; SCHWARTZ AC; FRAUMENI JF; HOOVER RN;
Indirizzi:
NIH,DIV CANC EPIDEMIOL & GENET,EXECUT PLAZA N,RM 418 BETHESDA MD 20892 NIH,OFF DIRECTOR BETHESDA MD 20892 MED UNIV S CAROLINA CHARLESTON SC 29425 MICHIGAN STATE UNIV,COLL HUMAN MED E LANSING MI 48824 NEW JERSEY STATE DEPT HLTH,SPECIAL EPIDEMIOL PROGRAM TRENTON NJ 08625 ALLEGHENY UNIV HLTH SCI,MCP HAHNEMANN SCH MED PHILADELPHIA PA 19102
Titolo Testata:
Journal of the National Cancer Institute
fascicolo: 22, volume: 90, anno: 1998,
pagine: 1710 - 1719
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAST MEDICAL HISTORY; UNITED-STATES; RISK-FACTORS; EXOCRINE PANCREAS; NUTRIENT INTAKE; COFFEE; ALCOHOL; CHOLECYSTOKININ; CARCINOGENESIS; CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
D.T. Silverman et al., "DIETARY AND NUTRITIONAL FACTORS AND PANCREATIC-CANCER - A CASE-CONTROL STUDY BASED ON DIRECT INTERVIEWS", Journal of the National Cancer Institute, 90(22), 1998, pp. 1710-1719

Abstract

Background: The relationship between diet and pancreatic cancer remains unclear, In this study, we assessed the role of diet and nutrition as risk factors for pancreatic cancer, using data obtained from directinterviews only, rather than data from less reliable interviews with next of kin. We evaluated whether dietary factors could explain the higher incidence of pancreatic cancer experienced by black Americans compared with white Americans. Methods: We conducted a population-based ease-control study of pancreatic cancer diagnosed in Atlanta (GA), Detroit (MI), and 10 New Jersey counties from August 1986 through April 1989, Reliable dietary histories were obtained for 436 patients and 2003general-population control subjects aged 30-79 years. Results: Obesity was associated with a statistically significant 50%-60% increased risk of pancreatic cancer that was consistent by sex and race. Although the magnitude of risk associated with obesity was identical in blacks and whites, a higher percentage of blacks mere obese than were whites (women: 38% versus 16%; men: 27% versus 22%), A statistically significant positive trend in risk was observed with increasing caloric intake, with subjects in the highest quartile of calorie intake experiencinga 70% higher risk than those in the lowest quartile, A statistically significant interaction between body mass index (weight in kg/height in m(2) for men and weight in kg/height in m(1.5) for women) and total caloric intake was observed that was consistent by sex and race. Subjects in the highest quartile of both body mass index and caloric intakehad a statistically significant 180% higher risk than those in the lowest, quartile, Conclusions: Obesity is a risk factor for pancreatic cancer and appears to contribute to the higher risk of this disease among blacks than among whites in the United States, particularly among women. Furthermore, the interaction between body mass index and caloricintake suggests the importance of energy balance in pancreatic carcinogenesis.

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Documento generato il 13/07/20 alle ore 09:19:45