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Titolo:
EFFECT OF FELINE IMMUNODEFICIENCY VIRUS ON CYTOKINE RESPONSE TO LISTERIA-MONOCYTOGENES IN-VIVO
Autore:
DEAN GA; BERNALES JA; PEDERSEN NC;
Indirizzi:
N CAROLINA STATE UNIV,COLL VET MED,DEPT MICROBIOL PATHOL & PARASITOL,4700 HILLSBOROUGH ST RALEIGH NC 27606 UNIV CALIF DAVIS,SCH VET MED,DEPT MED & EPIDEMIOL LIVERMORE CA 95616
Titolo Testata:
Veterinary immunology and immunopathology
fascicolo: 2-4, volume: 65, anno: 1998,
pagine: 125 - 138
SICI:
0165-2427(1998)65:2-4<125:EOFIVO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELAYED-TYPE HYPERSENSITIVITY; T-CELLS; INTRACELLULAR BACTERIA; IL-10 SYNERGIZES; LYMPH-NODE; TNF-ALPHA; INFECTION; CATS; MACROPHAGES; IMMUNITY;
Keywords:
FIV; HIV; LISTERIA MONOCYTOGENES; CYTOKINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Dean et al., "EFFECT OF FELINE IMMUNODEFICIENCY VIRUS ON CYTOKINE RESPONSE TO LISTERIA-MONOCYTOGENES IN-VIVO", Veterinary immunology and immunopathology, 65(2-4), 1998, pp. 125-138

Abstract

Feline immunodeficiency virus (FIV) is a lentivirus that induces an acquired immunodeficiency in domestic cats. The objective of this studywas to compare the immune response of chronically FIV-infected cats and specific pathogen free (SPF) cats to Listeria monocytogenes, a facultative intracellular bacterium. Regional lymph nodes were removed at various times after subcutaneous inoculation with L. monocytogenes andevaluated. Lymph nodes of chronically FIV-infected cats enlarged moreslowly and to a lesser degree than SPF cats. This was due to delayed and blunted lymphoid follicle formation and markedly diminished histiocyte influx. The cellular response correlated with a marked upregulation in IL10 transcription and delayed increase in TNF-alpha upregulation in FIV-infected cats. Transcriptional upregulation of IFN-gamma, IL4, and the p40 chain of IL12 was similar in lymph nodes of FIV-infectedand SPF cats. Clinically, FIV-infected cats had a more severe response at the site of L. monocytogenes injection and showed signs of systemic bacterial dissemination while SPF cats remained clinically normal. FIV-infected cats generated a delayed hypersensitivity response similar to SPF cats but also had a significantly greater antibody response. Taken together, these data suggest excessive IL10 production may be responsible for the deficiency observed in the innate immune response ofchronically FIV-infected cats challenged with L. monocytogenes. (C) 1998 Published by Elsevier Science B.V. AU rights reserved.

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Documento generato il 04/07/20 alle ore 14:07:22