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Titolo:
TH1 TH2 CYTOKINE EXPRESSION IN SALIVA OF HIV-POSITIVE AND HIV-NEGATIVE INDIVIDUALS - A PILOT-STUDY IN HIV-POSITIVE INDIVIDUALS WITH OROPHARYNGEAL CANDIDIASIS/
Autore:
LEIGH JE; STEELE C; WORMLEY FL; LUO W; CLARK RA; GALLAHER W; FIDEL PL;
Indirizzi:
LOUISIANA STATE UNIV,MED CTR,DEPT MICROBIOL IMMUNOL & PARASITOL,1901 PERDIDO ST NEW ORLEANS LA 70119 LOUISIANA STATE UNIV,MED CTR,DEPT MICROBIOL IMMUNOL & PARASITOL NEW ORLEANS LA 70119 LOUISIANA STATE UNIV,MED CTR,DEPT GEN DENT NEW ORLEANS LA 70119 LOUISIANA STATE UNIV,MED CTR,DEPT INTERNAL MED NEW ORLEANS LA 70119
Titolo Testata:
Journal of acquired immune deficiency syndromes and human retrovirology
fascicolo: 4, volume: 19, anno: 1998,
pagine: 373 - 380
SICI:
1077-9450(1998)19:4<373:TTCEIS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
VULVO-VAGINAL CANDIDIASIS; PAROTID-SALIVA; MUCOCUTANEOUS CANDIDIASIS; ORAL MANIFESTATIONS; IN-VITRO; INFECTION; WOMEN; TH1; ALBICANS; IGA;
Keywords:
HIV; CYTOKINES; TH1/TH2; CANDIDIASIS; ORAL MUCOSA; CANDIDA ALBICANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
J.E. Leigh et al., "TH1 TH2 CYTOKINE EXPRESSION IN SALIVA OF HIV-POSITIVE AND HIV-NEGATIVE INDIVIDUALS - A PILOT-STUDY IN HIV-POSITIVE INDIVIDUALS WITH OROPHARYNGEAL CANDIDIASIS/", Journal of acquired immune deficiency syndromes and human retrovirology, 19(4), 1998, pp. 373-380

Abstract

Current data suggest that T-helper (Th)2-type cytokine responses are often associated with progression to AIDS in HIV-positive individuals. Similarly, Th2-type cytokines are associated with susceptibility to mucosal candidiasis, of which oropharyngeal candidiasis (OPC) is one ofthe most common opportunistic infections in HIV-positive individuals. Although little information is available on host defense mechanisms at the level of the oral mucosa, recent studies suggest that local cell-mediated immunity (CMI) is equally or more important than that in theperiphery for host defense against mucosal Candida albicans infections. This study investigated the potential presence of oral-associated CMI through the expression of Th1/Th2-type cytokines in saliva of immunocompetent and immunocompromised individuals with and without OPC. Results showed a constitutive mixed Th1/Th2 cytokine expression (Th0) in whole saliva of healthy HIV-negative individuals. In contrast, HIV-positive individuals had a dominant Th2-type salivary cytokine profile (interleukin-4 [IL-4], IL-10) (IL-2, interferon-gamma [IFN-gamma], IL-12) that seemingly resulted from a lack of Th1-type cytokines rather than enhanced Th2-type cytokines. Moreover, pilot analyses of those with OPC showed evidence for a more profound salivary Th2-type profile. Both HIV-positive and HIV-negative patients, irrespective of CD4 counts, had some level of positive in vitro systemic lymphocyte proliferative responses to C albicans antigens, These results suggest that the Th1/Th2 cytokine dichotomy in HIV disease is detectable in situ in oral secretions and may be a useful indicator of oral-associated CMI to betterunderstand resistance/susceptibility of HIV-positive individuals to oral opportunistic infections, including OPC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:18:16