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Titolo:
ROLE OF CYTOKINES IN AIDS WASTING
Autore:
CHANG HR; DULLOO AG; BISTRIAN BR;
Indirizzi:
HARVARD UNIV,SCH MED,BETH ISRAEL DEACONESS MED CTR,DEPT MED,CANC RES INST,LAB NUTR INFECT BOSTON MA 02215 HARVARD UNIV,SCH MED,BETH ISRAEL DEACONESS MED CTR,DEPT MED,CANC RES INST,LAB NUTR INFECT BOSTON MA 02215 UNIV GENEVA,SCH MED,DEPT PHYSIOL,CTR MED UNIV CH-1211 GENEVA SWITZERLAND
Titolo Testata:
Nutrition (Burbank, Los Angeles County, Calif.)
fascicolo: 11-12, volume: 14, anno: 1998,
pagine: 853 - 863
SICI:
0899-9007(1998)14:11-12<853:ROCIAW>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; HUMAN-IMMUNODEFICIENCY-VIRUS; INTERLEUKIN-1 RECEPTOR ANTAGONIST; CORTICOTROPIN-RELEASING FACTOR; RESTING ENERGY-EXPENDITURE; NEUROPEPTIDE-Y CONCENTRATIONS; UBIQUITIN-PROTEASOME PATHWAY; MUSCLE PROTEIN BREAKDOWN; PITUITARY-ADRENAL AXIS; BODY-WEIGHT LOSS;
Keywords:
CYTOKINES; WASTING; CACHEXIA; MALNUTRITION; HIV; AIDS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
172
Recensione:
Indirizzi per estratti:
Citazione:
H.R. Chang et al., "ROLE OF CYTOKINES IN AIDS WASTING", Nutrition (Burbank, Los Angeles County, Calif.), 14(11-12), 1998, pp. 853-863

Abstract

There is now a large literature implicating cytokines in the development of wasting and cachexia commonly observed in a variety of pathophysiologic conditions. In the acquired immunodeficiency syndrome (AIDS),cytokines elicited by primary and secondary infections seem to exert subtle and sustained effects on behavioral, hormonal, and metabolic axes, and their combined effects on appetite and metabolism have been postulated to drive wasting. However, correlations of increased blood levels of a particular cytokine with wasting in AIDS have not been consistent observations, perhaps because cytokines act principally as paracrine and autocrine hormones, as well as indirectly by activating othersystems. A better understanding of the mechanisms underlying the catabolic effects of cytokines is clearly needed if more efficacious strategies are to be developed for the prevention and treatment of wasting in AIDS. In this review we first examine the interacting factors contributing to the AIDS wasting syndrome. We then analyze the complex and overlapping role of cytokines in the pathophysiology of this condition, and put forward a number of hypotheses to explain some of the most important features of this syndrome. (C) Elsevier Science Inc. 1998.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:45:52