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Titolo:
DIET AND NASOPHARYNGEAL CANCER IN A LOW-RISK POPULATION
Autore:
FARROW DC; VAUGHAN TL; BERWICK M; LYNCH CF; SWANSON GM; LYON JL;
Indirizzi:
FRED HUTCHINSON CANC RES CTR,PROGRAM EPIDEMIOL,1100 FAIRVIEW AVE NO,POB 19024,MP-474 SEATTLE WA 98109 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98195 YALE UNIV,DEPT EPIDEMIOL & PUBL HLTH NEW HAVEN CT 06520 UNIV IOWA,DEPT PREVENT MED & ENVIRONM HLTH IOWA CITY IA 52242 MICHIGAN STATE UNIV,COLL HUMAN MED E LANSING MI 48824 MICHIGAN STATE UNIV,CTR CANC E LANSING MI 48824 UNIV UTAH,DEPT FAMILY MED SALT LAKE CITY UT 00000
Titolo Testata:
International journal of cancer
fascicolo: 6, volume: 78, anno: 1998,
pagine: 675 - 679
SICI:
0020-7136(1998)78:6<675:DANCIA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
VOLATILE NITROSAMINE LEVELS; SALTED FISH; CARCINOMA NPC; CHINA; SMOKING; EPIDEMIOLOGY; FOODS; AREAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
D.C. Farrow et al., "DIET AND NASOPHARYNGEAL CANCER IN A LOW-RISK POPULATION", International journal of cancer, 78(6), 1998, pp. 675-679

Abstract

Asian studies have reported that risk of nasopharyngeal cancer (NPC) is increased in individuals who frequently consume salted fish, which contains high levels of N-nitroso compounds. As part of a collaborative, population-based, case-control study in the U.S., where the annual incidence of the disease is low, we investigated whether dietary intake of preformed nitrosamines or nitrosamine precursors, or of antioxidants including vitamin C and carotenoids, was associated with altered risk of NPC overall, or of specific histologic subtypes of disease. Cases (n = 133) identified at 5 population-based cancer registries and controls (n = 212) identified through random digit dialing completed a telephone interview and self-administered food frequency questionnaire. Dietary exposures were expressed as quartiles of intake, and odds ratios (ORs) calculated using the lowest quartile of intake as the reference category. Risk of non-keratinizing and undifferentiated tumors of the nasopharynx was increased in frequent consumers of preserved meats, which contain high levels of added nitrites. ORs in the 2nd, 3rd andhighest quartile were 1.99, 4.35 and 4.59, although 95% confidence intervals did not exclude 1.0. Risk of differentiated squamous cell carcinoma, but not other histologic types, was significantly reduced in individuals with vitamin C intake above the lowest quartile (ORs 0.30, 0.33 and 0.30 in the 2nd, 3rd and highest quartiles, respectively). This association was markedly stronger among non-smokers and former smokers than among current smokers. Finally, individuals who reported consuming supplemental vitamins were at an approximately 50% reduced risk of NPC. Our results indicate that future studies should consider the effects of dietary risk factors on the risk of specific histologic subsets of NPC, and not assume that the disease is etiologically homogeneous. (C) 1998 Wiley-Liss, Inc.

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Documento generato il 05/07/20 alle ore 12:36:53