Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
VENOUS VERSUS ARTERIAL ACTIONS OF DIETHYLAMINE NITRIC OXIDE (DEA/NO) COMPLEX AND S-NITROSO-N-ACETYLPENICILLAMINE (SNAP) IN-VIVO/
Autore:
NG SSW; PANG CCY;
Indirizzi:
UNIV BRITISH COLUMBIA,FAC MED,DEPT PHARMACOL & THERAPEUT,2176 HLTH SCI MALL VANCOUVER BC V6T 1Z3 CANADA UNIV BRITISH COLUMBIA,FAC MED,DEPT PHARMACOL & THERAPEUT VANCOUVER BCV6T 1Z3 CANADA
Titolo Testata:
British Journal of Pharmacology
fascicolo: 6, volume: 125, anno: 1998,
pagine: 1247 - 1251
SICI:
0007-1188(1998)125:6<1247:VVAAOD>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTROLLED BIOLOGICAL RELEASE; CIRCULATORY FILLING PRESSURE; NITRIC-OXIDE; VASCULAR RELAXATION; L-ARGININE; NUCLEOPHILES; VASODILATORS; MECHANISM; AGENTS; DRUGS;
Keywords:
NO/NUCLEOPHILE COMPLEX; S-NITROSOTHIOL; SODIUM NITROPRUSSIDE; NITROGLYCERIN; CAPACITANCE VESSELS; MEAN CIRCULATORY FILLING PRESSURE; VENOUS RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
S.S.W. Ng e C.C.Y. Pang, "VENOUS VERSUS ARTERIAL ACTIONS OF DIETHYLAMINE NITRIC OXIDE (DEA/NO) COMPLEX AND S-NITROSO-N-ACETYLPENICILLAMINE (SNAP) IN-VIVO/", British Journal of Pharmacology, 125(6), 1998, pp. 1247-1251

Abstract

1 We studied the effects of diethylamine/NO complex (DEA/NO) and S-nitroso-N-acetylpenicillamine (SNAP), relative to those of sodium nitroprusside (SNP) and nitroglycerin (NTG), on mean arterial pressure (MAP), mean circulatory filling pressure (MCFP), arterial resistance (R-a),venous resistance (R-v), heart rate (HR), cardiac output (CO) and stroke volume (SV) in groups of Inactin-anaesthetized rats pre-treated with i.v. mecamylamine (3.7 mu mol kg(-1)) and noradrenaline (6.8 nmol kg(-1) min(-1)). Doses of each that reduced MAP by 30%, 80% and the lowest dose that maximally reduced MAP were examined to allow a comparison of the compounds' dilator actions at equivalent effective depressor doses. 2 DEA/NO (4, 32 and 256 mu g kg(-1) min(-1)), SNAP (4, 32 and 256 mu g kg(-1) min(-1)) and SNP (8, 32 and 128 mu g kg(-1) min(-1)) caused similar dose-dependent reductions in MAP and R-a, and increases in CO and SV. NTG (0.2, 0.8 and 6.3 pg kg(-1) min(-1)) dose-dependentlyreduced R-a, and increased CO and SV, but lowered MAP only at the highest dose. 3 DEA/NO, SNAP and SNP but not NTG lowered MCFP with efficacy: DEA/NO > SNAP > SNP. Al four drugs reduced R-v with efficacy: DEA/NO approximate to SNAP>SNP approximate to NTG. 4 Therefore, all compounds lowered R-a and R-v. DEA/NO, SNAP and SNP but not NTG reduced MCFP. The pharmacological profiles of DEA/NO and SNAP resemble SNP more than NTG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:28:03